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Methods For The Investigation Of Microvascular Control Of Oxygen Distribution, Richard Sove
Methods For The Investigation Of Microvascular Control Of Oxygen Distribution, Richard Sove
Electronic Thesis and Dissertation Repository
The purpose of this thesis was to develop tools for studying oxygen-dependent regulation of red blood cell (RBC) flow distribution in the microcirculation. At the microvascular level, arterioles dictate the distribution of oxygen (O2) carrying RBCs to downstream capillaries, a process which needs to be tightly regulated and coupled to O2 off loading from capillaries to the tissue. To investigate potential regulatory mechanisms, an O2 exchange platform was developed to manipulate the RBC hemoglobin O2 saturation (SO2) at the muscle surface while limiting the changes in SO2 to only a single capillary …