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- Adrenergic Vascular Responses (1)
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- Computed Tomography Perfusion (1)
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Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Applications Of Ct Perfusion-Based Triaging And Prognostication In Acute Ischemic Stroke, Eric A. Wright
Applications Of Ct Perfusion-Based Triaging And Prognostication In Acute Ischemic Stroke, Eric A. Wright
Electronic Thesis and Dissertation Repository
CT Perfusion (CTP) is a minimally invasive imaging technique that aids acute ischemic stroke (AIS) triage and prognostication by determining tissue viability based on hemodynamic parameters. The goals of this research are to determine: 1) CTP thresholds for estimation of infarct and penumbra volume, 2) how CTP scan duration impacts infarct and penumbra volume estimates, and 3) reliability of CTP for predicting functional outcomes following intra-arterial therapy (IAT).
Chapter 2 introduced an experimental study for determining ischemia-time dependent thresholds for brain infarction using multimodal imaging in a porcine stroke model that is easier to implement than previous large animal stroke …
Multi-Scale Peripheral Vasculopathy With Metabolic Syndrome, Kent Lemaster
Multi-Scale Peripheral Vasculopathy With Metabolic Syndrome, Kent Lemaster
Electronic Thesis and Dissertation Repository
The combination of cardiovascular and metabolic risk factors including obesity, dyslipidemia, hypertension, and insulin resistance, in combination with a prothrombotic and proinflammatory state, is a condition termed Metabolic Syndrome (METS). Twenty percent of the adult population is afflicted with METS which increases the risk of type-2 diabetes mellitus and cardiovascular disease. Further, the presence of peripheral vascular disease (PVD) is tightly coupled with METS which is a perfusion-demand mismatch of blood supply to active skeletal muscle resulting in painful claudication and a late-stage potential for amputation. The underlying contributors of METS associated micro-vasculopathies in the skeletal muscle, their impact on …
Methods For The Investigation Of Microvascular Control Of Oxygen Distribution, Richard Sove
Methods For The Investigation Of Microvascular Control Of Oxygen Distribution, Richard Sove
Electronic Thesis and Dissertation Repository
The purpose of this thesis was to develop tools for studying oxygen-dependent regulation of red blood cell (RBC) flow distribution in the microcirculation. At the microvascular level, arterioles dictate the distribution of oxygen (O2) carrying RBCs to downstream capillaries, a process which needs to be tightly regulated and coupled to O2 off loading from capillaries to the tissue. To investigate potential regulatory mechanisms, an O2 exchange platform was developed to manipulate the RBC hemoglobin O2 saturation (SO2) at the muscle surface while limiting the changes in SO2 to only a single capillary …