Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Tools For Improving High-Dose-Rate Prostate Cancer Brachytherapy Using Three-Dimensional Ultrasound And Magnetic Resonance Imaging, William T. Hrinivich
Tools For Improving High-Dose-Rate Prostate Cancer Brachytherapy Using Three-Dimensional Ultrasound And Magnetic Resonance Imaging, William T. Hrinivich
Electronic Thesis and Dissertation Repository
High-dose-rate brachytherapy (HDR-BT) is an interstitial technique for the treatment of intermediate and high-risk localized prostate cancer that involves placement of a radiation source directly inside the prostate using needles. Dose-escalated whole-gland treatments have led to improvements in survival, and tumour-targeted treatments may offer future improvements in therapeutic ratio. The efficacy of tumour-targeted HDR-BT depends on imaging tools to enable accurate dose delivery to prostate sub-volumes. This thesis is focused on implementing ultrasound tools to improve HDR-BT needle localization accuracy and efficiency, and evaluating dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) for tumour localization.
First, we implemented a device enabling …
Developments In Pet-Mri For Radiotherapy Planning Applications, John Christian Patrick
Developments In Pet-Mri For Radiotherapy Planning Applications, John Christian Patrick
Electronic Thesis and Dissertation Repository
The hybridization of magnetic resonance imaging (MRI) and positron emission tomography (PET) provides the benefit of soft-tissue contrast and specific molecular information in a simultaneous acquisition. The applications of PET-MRI in radiotherapy are only starting to be realised. However, quantitative accuracy of PET relies on accurate attenuation correction (AC) of, not only the patient anatomy but also MRI hardware and current methods, which are prone to artefacts caused by dense materials. Quantitative accuracy of PET also relies on full characterization of patient motion during the scan. The simultaneity of PET-MRI makes it especially suited for motion correction. However, quality assurance …