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Development Of A Translational Animal Model Of Sepsis, Nathaniel E. Hayward

Electronic Thesis and Dissertation Repository

Sepsis is an excessive inflammatory response to infection that leads to multiple organ failure. The high mortality rates in the intensive care unit have remained stagnant, which can be attributed to the disconnect between the bench and the bedside. There is a global need for an animal model of sepsis that is more relevant to the clinical scenario. We developed an in vivo rat model of sepsis, with a high level of instrumentation, to monitor macrovascular and microvascular changes over the course of a feces-induced peritonitis (FIP) .

In addition, early fluid resuscitation of septic patients is associated with better …