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Full-Text Articles in Medicine and Health Sciences
Kinetically Controlled Synthesis Of Triblock Copolymer Stabilized Gold Nanoparticles, Theodore Saleem Sabir
Kinetically Controlled Synthesis Of Triblock Copolymer Stabilized Gold Nanoparticles, Theodore Saleem Sabir
Loma Linda University Electronic Theses, Dissertations & Projects
Concerns for the environmental and economic impact of organic solvents in gold nanoparticle synthesis have motivated the search for more environmentally benign alternatives. One viable approach is the synthesis of AuNPs from tetrachloroauric(III) acid (HAuCl4) using triblock copolymers (TBPs). However, a major challenge of using TBPs is the heterogeneous nature of the formed nanocrystals. Establishing control over AuNP size and shape requires a detailed mechanistic understanding of precursor reduction and nanoparticle growth. By using mixtures of TBPs (L31 and F68), a more flexible method to tune AuNP size and shape is demonstrated. This is achieved by adjusting the TBP/Au(III) ratio …
The Impact Of Nucleoside Sugar Modification On Biochemical Dna Transactions, Adides Williams
The Impact Of Nucleoside Sugar Modification On Biochemical Dna Transactions, Adides Williams
Loma Linda University Electronic Theses, Dissertations & Projects
Discrimination by DNA polymerases controls the fidelity of DNA replication, and reduced fidelity results in mutations essential in the etiology of cancer. Polymerase discrimination operates at both dNTP insertion and subsequent elongation steps, and involves several energetic and structural factors that are as yet incompletely understood. While base pairing interactions have been studied extensively, substantially less is known about the role of sugar structure and conformation for polymerase incorporation and extension. In these studies we examined, systematically, the role of sugar structure and conformation on polymerase selection of the dNTP for insertion and polymerase elongation. To accomplish these goals, we …