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Full-Text Articles in Medicine and Health Sciences
Effects Of Aging & Exercise On Production Of Glial Cell Line-Derived Neurotrophic Factor Protein By Fast & Slow Skeletal Muscle, Maria Jaramillo
Effects Of Aging & Exercise On Production Of Glial Cell Line-Derived Neurotrophic Factor Protein By Fast & Slow Skeletal Muscle, Maria Jaramillo
Honors Theses
Exercise is a positive form of reinforcing positive lifestyle choices. There are many benefits to exercising such as decreased risk of cardiovascular disease and improved mental condition (Centers for Disease Control and Prevention). In addition, exercise can serve a protecting role for the nervous system. One form in which exercise can protect the nervous system is by increasing the production of neurotrophic factors, specifically glial cell line-derived neurotrophic factor. Another way by which exercise can protect the nervous system is by preserving muscle tissue due to actively recruiting it. The goal of this study was to explore the effects of …
Study Of The Insulin Mimetic Sodium Orthovanadate In Glucosamine Induced Insulin Resistnace In Primary Rat Hepatocytes, Kalan Mcpherson
Study Of The Insulin Mimetic Sodium Orthovanadate In Glucosamine Induced Insulin Resistnace In Primary Rat Hepatocytes, Kalan Mcpherson
Masters Theses
Insulin resistance and type II diabetes is a disease state characterized by a lack of sensitivity of insulin to provoke a proper response in insulin sensitive tissues. Currently, we utilize glucosamine to increase flux through the Hexosamine Biosynthetic Pathway (HBP) to induce an insulin resistance like state in primary rat hepatocytes. We tested the effectiveness of the insulin mimetic sodium orthovanadate to determine if it could elicit an insulin-like response under these conditions. Mixed results were obtained on the effectiveness of vanadate as an insulin mimetic in this insulin resistant model.
Roles And Regulation Of Nf-Xb In Platelet-Derived Growth Factor Transformed Cells, Takeshi Shimamura
Roles And Regulation Of Nf-Xb In Platelet-Derived Growth Factor Transformed Cells, Takeshi Shimamura
Dissertations
Platelet-derived growth factor (PDGF) is overexpressed in various cancer cells and the overexpression may be correlated with the prognosis of several types of cancers. Binding of PDGF to its receptors induces receptor dimerization and subsequent autophosphorylation of tyrosine residues in the receptor’s cytoplasmic domains. The phosphorylated tyrosine residues interact with the secondary signaling molecules to initiate signaling cascades that trigger cellular changes by affecting downstream effectors. In our recent publication, we have shown that a NF-icB mediates the transformation of mouse fibroblast cells overexpressing PDGF B chain. Though there is a significant correlation between PDGF stimulation and N F-kB activity, …
Sds Non-Acrylamide Polymeric Gel-Filled Capillary Electrophoresis For Molecular Size Separation Of Protein, Devon Andres
Sds Non-Acrylamide Polymeric Gel-Filled Capillary Electrophoresis For Molecular Size Separation Of Protein, Devon Andres
Honors Theses
Sodium dodecyl sulfide (SDS) non-acrylamide gel-filled capillary columns are a new technology being used for analysis and separation of biotechnology-derived proteins. This research was to compare this new technology to the current methods of SDS polyacrylamide gel electrophoresis (SDS-PAGE) and high-performance size-exclusion chromatography (HPSEC). The molecular mass of four different recombinant proteins were determined by two commercialized SDS non-acrylamide gel-filled capillary columns, SDS-PAGE, and HPSEC. The data obtained showed that the SDS non-acrylamide gel-filled capillary columns were compatible with the SDS-PAGE technique for molecular mass determination. HPSEC was shown to be unreliable for molecular weight determination. SDS non-acrylamide gel-filled capillary …