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Full-Text Articles in Medicine and Health Sciences
Vitamin D Levels And Risk Of Dyslipidemia Among Us Children With Diabetes And Obesity, Elsina E. Hagan
Vitamin D Levels And Risk Of Dyslipidemia Among Us Children With Diabetes And Obesity, Elsina E. Hagan
Masters Theses 1911 - February 2014
Dyslipidemia is increasing among U.S. children, and the prevalence is highest among children with diabetes and obesity. Recently, vitamin D deficiency has been suggested as a possible dietary risk factor for dyslipidemia. Despite the high prevalence of vitamin D deficiency amongst children, virtually no studies have evaluated the association between vitamin D and dyslipidemia among children. We evaluated the vitamin D and dyslipidemia relationship among 240 children and adolescents aged 2 through 21 years who were outpatients of a pediatric endocrinology unit at a large tertiary care facility in Western Massachusetts from April 2008 to April 2010. Eligible children were …
Mechanisms That Regulate Peripheral Immune Responses To Control Organ Specific Autoimmunity, Gerard F. Hoyne
Mechanisms That Regulate Peripheral Immune Responses To Control Organ Specific Autoimmunity, Gerard F. Hoyne
Health Sciences Papers and Journal Articles
The immune system must balance the need to maintain a diverse repertoire of lymphocytes to be able to fight infection with the need to maintain tolerance to self proteins. The immune system places strict regulation over the ability of T cells to produce the major T cell growth factor interleukin 2 as this cytokine can influence a variety of immune outcomes. T cells require the delivery of two signals one through the antigen receptor and a second through the costimulatory receptor CD28. The immune system uses a variety of E3 ubiquitin ligases to target signaling proteins that function downstream of …
Mechanisms Of Translation Arrest Following Focal Brain Ischemia, Monique K. Lewis
Mechanisms Of Translation Arrest Following Focal Brain Ischemia, Monique K. Lewis
Wayne State University Dissertations
MECHANISMS OF TRANSLATION ARREST FOLLOWING FOCAL BRAIN
ISCHEMIA
by
MONIQUE K. LEWIS
August 2011
Advisor: Dr. Donald DeGracia
Major: Physiology
Degree: Doctor of Philosophy
The loss of blood flow to the brain is termed ischemia and the subsequent resumption of blood flow is termed reperfusion. Brain ischemia and reperfusion (I/R) occurs primarily following resuscitation from cardiac arrest and stroke and presents one of the most significant clinical challenges. At present, there are no clinically effective pharmacologic interventions to halt brain damage following I/R. The major Aim of this dissertation will be to investigate possible mechanisms involved in neuron death following …