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Full-Text Articles in Medicine and Health Sciences
Acute Effects Of Neuromuscular Electrical Stimulation On Blood Glucose And Energy Metabolism In Overweight/Obese Population, Ali Mossayebi
Acute Effects Of Neuromuscular Electrical Stimulation On Blood Glucose And Energy Metabolism In Overweight/Obese Population, Ali Mossayebi
Open Access Theses & Dissertations
Background: In the perspective of preventing cardiovascular disease and promoting health, weight control and physical activity are the main concerns. Electrical stimulation (ES) is an alternate strategy to induce muscle contraction, using electrical impulses. However, effectiveness of ES induced muscle contraction to improve energy expenditure and glucose metabolism is not well examined.Purpose: To determine the acute effect of ES on whole body energy expenditure and body glucose metabolism in sedentary overweight or obese population Methods: Sedentary overweight/obese participants (n=8; age: 37.25 ± 6.09 years; BMI= 37.57 ± 2.43 kg/m2) were included in this study. All participants received bilateral quadriceps ES …
Autoantibody Against Tumor-Associated Antigens As Diagnostic Biomarkers In Hispanic Patients With Hepatocellular Carcinoma, Yangcheng Ma
Autoantibody Against Tumor-Associated Antigens As Diagnostic Biomarkers In Hispanic Patients With Hepatocellular Carcinoma, Yangcheng Ma
Open Access Theses & Dissertations
Liver cancer is one of the most prevalent malignancies, in which hepatocellular carcinoma (HCC) takes up more than 80% of liver cancer cases. Early diagnosis and treatment are practical approaches to impede HCC progression. Identifying and classifying autoantibodies against tumor-associated antigens (TAAs) have long been interested in cancer diagnosis, especially for HCC. Circulating anti-TAA autoantibodies amplify the antigen expression and are more stable in blood, guaranteeing anti-TAA autoantibodies as valid diagnostic biomarkers in clinical application. Nonetheless, very few studies had focused on the Hispanic HCC group, which might retain distinct etiological risk factors compared to other ethnicities. The high incidence …
Regulation Of C-C Chemokine Receptor 7 (Ccr7) Ligand-Mediated Internalization And Chemotaxis By G Protein-Coupled Receptor Kinase Family 4 (Grk-4, 5, 6) In Human Pediatric T-Cell Acute Lymphoblastic Leukemia (T-All), Eduardo Elias Chaib
Open Access Theses & Dissertations
Background and Significance: The Hispanic population is disproportionally affected by T-ALL (T-cell acute lymphoblastic leukemia) when compared to other races in the US. C-C Chemokine Receptor 7 (CCR7) in T-ALL is used during disease progression, and may lead to migration of cancerous cells into the Central Nervous System (CNS) of patients. Goals and Objectives: This project aims to find relevant rates and risk factors for T-ALL for the Hispanic population in the US/Mexico border region. The other aim is to assess the effect of the G protein-coupled Receptor Kinase 4 (GRK-4) family proteins on migration and receptor internalization through CCR7 …
Targeting Delivery Of Bcl-2 Family Protein Inhibitor Has The Potential To Treat Cancer And Fibrosis, Mohammad Nurul Huda
Targeting Delivery Of Bcl-2 Family Protein Inhibitor Has The Potential To Treat Cancer And Fibrosis, Mohammad Nurul Huda
Open Access Theses & Dissertations
Apoptosis is a naturally occurring cell death mechanism to remove the selective cell population. B-cell leukemia/lymphoma-2 (BCL-2) family protein plays a critical role in activating the upstream apoptosis signaling pathway, primarily the intrinsic apoptosis pathway. The BCL-2 family consists of both pro-and anti-apoptotic proteins, which are structurally and functionally similar, containing up to four BCL-2 homologies (BH) motifs (BH1-4). Defecting apoptosis along this signaling pathway can lead to various events, including malignant cell transformation, tumor metastasis, tissue fibrosis, and drug resistance. In fibrosis, the aberrant apoptosis signaling also activates multiple effector proteins and growth factors, such as TGF-β, CTGF, and …