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Full-Text Articles in Medicine and Health Sciences
Consequences Of Increased Cd45ra And Rc Isoforms For Tcr Signaling And Peripheral T Cell Deficiency Resulting From Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation, Zuopeng Wu, Adele L. Yates, Gerard F. Hoyne, Christopher C. Goodnow
Consequences Of Increased Cd45ra And Rc Isoforms For Tcr Signaling And Peripheral T Cell Deficiency Resulting From Heterogeneous Nuclear Ribonucleoprotein L-Like Mutation, Zuopeng Wu, Adele L. Yates, Gerard F. Hoyne, Christopher C. Goodnow
Health Sciences Papers and Journal Articles
CD45 is the most abundant protein tyrosine phosphatase in the plasma membrane of T cells and serves a critical role in TCR signaling. Different CD45 isoforms are made by alternative mRNA splicing depending on the stage of T cell development and activation, yet their role remains unclear. Expression of CD45RA and RC isoforms is increased 20- to 200-fold on T cells from thunder mice with a loss-of-function mutation in the RNA-binding protein, heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL), although total CD45 expression is unaltered. In this study, we test the hypothesis that this shift in CD45 isoform expression alters TCR signaling, …