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Full-Text Articles in Medicine and Health Sciences
Characterization And Manipulation Of O-Glcnacylation In Granulosa Cells Of Bovine Ovarian Antral Follicles, Abigail Marie Maucieri
Characterization And Manipulation Of O-Glcnacylation In Granulosa Cells Of Bovine Ovarian Antral Follicles, Abigail Marie Maucieri
Graduate College Dissertations and Theses
Glucose is widely recognized as the preferred energy substrate for metabolism by granulosa cells (GCs). Yet in most cells, 2-5% of glucose is shunted through the hexosamine biosynthesis pathway (HBP) for O-linked N-acetylglucosaminylation (O-GlcNAcylation). O-GlcNAcylation is an evolutionarily-conserved, post-translational process that modifies serine and threonine residues on a variety of proteins. O-GlcNAcylation is also considered a nutrient sensor that can regulate cellular processes such as metabolism, signal transduction, and proliferation. In this respect, O-GlcNAcylation may be similar to, and possibly mediate, AMP-activated protein kinase (AMPK) signaling and its nutrient-sensing actions. However, the occurrence of O-GlcNAcylation and its relative importance to …
Mitochondrial Dynamics Regulation Of The Lung Epithelial Response To Complex Allergen, Sierra White
Mitochondrial Dynamics Regulation Of The Lung Epithelial Response To Complex Allergen, Sierra White
Graduate College Dissertations and Theses
Asthma is a chronic inflammatory disease of the lungs that affects roughly 25 million Americans, costing the United States upwards of $80 billion annually in management and economic loss. The airway epithelium, which serves as the first line of defense against insults in the lung, are now appreciated as key contributors to initiation of this disease. A key regulator of the epithelial response to allergens and other inhaled irritants that can induce an allergic asthmatic response is the mitochondria. During an allergic response, the airway epithelial energy requirement changes, and mitochondrial function is altered, enhancing production of reactive oxygen species, …
Building A Learning Healthcare System: A Path To Optimizing Big Health Data To Inform Clinical Care Decisions, Danne Charlotte Emily Elbers
Building A Learning Healthcare System: A Path To Optimizing Big Health Data To Inform Clinical Care Decisions, Danne Charlotte Emily Elbers
Graduate College Dissertations and Theses
The explosive growth of data and computing power of the last decades has had large impacts on a myriad of domains, not in the least on one of society’s most complex systems: healthcare. In this work, a version of the resulting Learning Healthcare System (LHS) is explored and elements of it have been implemented and are in use at the Department of Veterans’ Affairs today. After an overview of what a LHS is and what it could be once executed in its full form, the chapters will describe in detail some of the individual elements and how they address cogs …
The Effect Of Amphibian Host Ecology And Evolution On The Pathogen Dynamics Of Ranavirus, Lauren V. Ash
The Effect Of Amphibian Host Ecology And Evolution On The Pathogen Dynamics Of Ranavirus, Lauren V. Ash
Graduate College Dissertations and Theses
Emerging infectious diseases threaten amphibian species around the globe. Ranavirus (Family: Iridoviridae) is associated with the majority of amphibian deaths in North America, with some species exhibiting mass mortality events in short periods of time. In contrast, some amphibian species show the capacity to resist or tolerate infection. Resistant individuals exhibit reduced infection intensity, while tolerant individuals display reduced fitness effects given the infection intensity. My research focused on how amphibian host dynamics at community, population, and individual-level scales relate to the wide variation in Ranavirus prevalence and severity. Through my work, I documented the first reports of Ranavirus in …
Experiences Participating In Federal Nutrition Assistance Programs During The Early Months Of The Covid-19 Pandemic: A Mixed Methods Study In Vermont, Emma Haven Spence
Experiences Participating In Federal Nutrition Assistance Programs During The Early Months Of The Covid-19 Pandemic: A Mixed Methods Study In Vermont, Emma Haven Spence
Graduate College Dissertations and Theses
For many Americans, the impacts of the COVID-19 pandemic have extended far beyond its overt health risks, spanning from economic shocks to new social realities. Elevated rates of both novel and continued food insecurity during the pandemic have been well-documented, and this burden has not been equally shared. Examination of food insecurity at the present moment offers a unique opportunity to give voice to those affected during this unprecedented time and understand the ability of existing social services to meet increased needs. This research aims to delve into the experiences of individuals at risk for food insecurity. Specifically, (1) to …