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Determining Mediators Of Naive T Cell Motility And Dc Association In The Lymph Node, Janie R. Byrum
Determining Mediators Of Naive T Cell Motility And Dc Association In The Lymph Node, Janie R. Byrum
Biomedical Sciences ETDs
To become activated and perform effector functions, naive T cells move within lymph nodes to scan dendritic cells presenting antigen. Previous work has shown naive T cell activation is promoted by interleukin 7 in vivo, and it does so by regulating the T cell:dendritic cell interaction. Our work identifies a novel role for IL-7 in mediating naive T cell motility in the lymph node and promoting T cell association with DCs. Additionally, we have developed a method for analyzing microscopy images, regionalized normalized mutual information, to assess intercellular associations between T cells and other cells within the lymph node. Dendritic …