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Store-Operated Calcium Channels In The Function Of Intracardiac Neurons, Timetria Bonds
Store-Operated Calcium Channels In The Function Of Intracardiac Neurons, Timetria Bonds
USF Tampa Graduate Theses and Dissertations
Proper autonomic regulation of mammalian cardiac function is dependent upon very complex and precise communication among the intracardiac ganglia and individual neurons within the ganglia. An array of neuromodulators is found within the ganglia that direct neuronal activity by modulating the movement of calcium. The current study determines that opioidergic agonists, which have been found to contribute to severe cardiac disease states and intracellular calcium mobilization, are also responsible for changes in the function of the intracardiac neuron via their effects on store-operated calcium channels (SOCs).
Previous studies suggest that phosphorylation plays a role in SOC regulation. Using Fura-2 calcium …