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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Characterization Of Nrk2b Overexpression In A Transgenic Zebrafish Congenital Muscular Dystrophy Model, Anna Burgess
Characterization Of Nrk2b Overexpression In A Transgenic Zebrafish Congenital Muscular Dystrophy Model, Anna Burgess
Honors College
Everyday movement, whether sitting or running a marathon, exerts stressful forces on myotendinous junctions (MTJs). As the sites which skeletal muscle fibers anchor to surrounding extracellular matrix (ECM) material of tendon, MTJs need to maintain homeostasis under stress for muscle to function normally. Human congenital muscular dystrophies (CMDs) are a heterogeneous group of diseases that disrupt muscle homeostasis, are severely debilitating, and currently have no cure. In many CMDs, genetic mutations effect cell adhesion complexes located at the MTJ. The adherence of muscle fibers’ cytoskeleton to the extracellular matrix (ECM) is weakened when these complexes as compromised. Many genes resulting …
Collaborative Research: North East Cyberinfrastructure Consortium, Michael Eckardt
Collaborative Research: North East Cyberinfrastructure Consortium, Michael Eckardt
University of Maine Office of Research Administration: Grant Reports
EPS-0918284, University of Vermont & State Agricultural College, J. L. Van Houten, linked to EPS-0918033 (University of New Hampshire), EPS-0918078 (University of Delaware), EPS-0918018 (University of Maine), EPS-0918061 (University of Rhode Island)
Collaborative Research: North East Cyberinfrastructure Consortium
This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5).
The North East Cyberinfrastructure Consortium (NECC) unites Maine (ME), New Hampshire (NH), Vermont (VT), Rhode Island (RI), and Delaware (DE) to support cyber-enabled research that requires analyses of large datasets. The project is organized around sharing resources, expertise and facilities in order to make cyber-enabled collaborative …
Cell-Matrix Adhesion In Muscle Development And Disease, Michelle F. Goody
Cell-Matrix Adhesion In Muscle Development And Disease, Michelle F. Goody
Electronic Theses and Dissertations
A variety of diseases, both inherited and acquired, affect muscle tissues in humans. The anchoring of muscle fibers to their surrounding environment is critical for muscle homeostasis. Muscle fibers attach to their microenvironment through cell-matrix adhesion complexes. These anchoring complexes are placed under repeated stress during muscle contraction. Genetic mutations in these complexes weaken the attachment between muscle fibers and their microenvironment, making fibers more susceptible to damage and death. This increased fiber degeneration eventually leads to progressive muscle wasting diseases, known as congenital muscular dystrophies. Although clinical trials are ongoing, there is presently no way to cure the loss …
Identification Of Internal Parasites Of Sheep And Goats, Amanda Chaney
Identification Of Internal Parasites Of Sheep And Goats, Amanda Chaney
Honors College
Abomasal worms are a major cause of small ruminant disease. Differentiation of the most pathogenic nematode, H. contortus, from the other common species can be difficult using standard diagnostic fecal floatation techniques because the ova are similar in size and morphology. Known pure culture H. contortus fecal samples from West Virginia University were used to develop morphologic assays using FITC-labeled lectin agglutination and immunocytochemistry to identify species of abomasal worms. These assays were applied to assess disease due to abomasal worms on selected small ruminant farms in Maine. The diagnostic tests were used to test the hypothesis that H. contortus …