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Articles 1 - 14 of 14
Full-Text Articles in Medicine and Health Sciences
An Analysis Of Water Quality At Orange County, California Beaches, Naomi Meurice
An Analysis Of Water Quality At Orange County, California Beaches, Naomi Meurice
Pomona Senior Theses
Beaches in Southern California are highly recreated by residents and visitors, making beaches socially and economically important. Public health departments in coastal communities are in charge of measuring water quality and ensuring it is safe for users. Research in the past has indicated that beach water quality gets worse after storms, with bacteria levels jumping on the day of a storm and staying high for up to five days. Studies have shown these spikes in bacteria to be associated with storm runoff, with beaches closer to runoff discharge locations experiencing more impact. However, prior research has not considered the period …
Copy Number Alterations Of Aggressive Pituitary Neuroendocrine Tumors, Grace Zhang
Copy Number Alterations Of Aggressive Pituitary Neuroendocrine Tumors, Grace Zhang
Scripps Senior Theses
Pituitary neuroendocrine tumors (PitNETs) are tumors of the pituitary gland. Although most are benign, they can cause severe morbidity if compression of surrounding tissue and/or endocrinopathies occur.
Aggressive PitNETs are notably detrimental and difficult to predict, and their effects are further exacerbated by challenges in treatment. Although histological studies can detect certain markers of tumor aggressiveness, they are insufficient at wholly predicting PitNET aggressiveness, making the clinical behavior of PitNETs challenging to determine. Since treatment of aggressive tumors also remains suboptimal, this further results in negative impacts on health and quality of life.
Genetic markers, such as copy number variations …
Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner
Oral Contraceptives And Affective Disorders: Neurobiology And Informed Choice, Sophia Mae Drezner
Scripps Senior Theses
Pregnancy prevention and female reproductive freedom have been some of the most contested political issues for decades. Abortion, a fundamental part of women’s healthcare, divides liberals and conservatives on an international scale. The consequences of unintended pregnancy without safe and reliable contraception are widespread, disproportionately impacting women of color, trans and non-binary folks, and poorer communities. The birth control pill is the most common form of oral contraception (OC) globally. Many people with ovaries begin the pill or other hormonal contraceptive (HC) methods as young as 11 years old. Exogenous progesterone and estrogen are known to impact mood, affect, physiology, …
Cultivating Carrots, Community, And Health-Conscious Children: Investigating The Effects Of Community Garden Implementation On Nutrition Attitudes Of Elementary Students In The Los Angeles Unified School District, Hannah Michele Tiedemann
Cultivating Carrots, Community, And Health-Conscious Children: Investigating The Effects Of Community Garden Implementation On Nutrition Attitudes Of Elementary Students In The Los Angeles Unified School District, Hannah Michele Tiedemann
Scripps Senior Theses
Growing up in an urban food desert can significantly affect children's development, health, and well-being (Jencks et al., 1990; Leventhal et al., 2000). Compared to their more affluent peers, youth living in low-socioeconomic urban neighborhoods are at greater risk of experiencing poor-quality diets, food insecurity, unhealthy body weights, and mental health problems (Duncan et al., 1997; Sampson et al., 1997). Moreover, children living in food-insecure households are more likely to consume calorically dense diets high in trans fat and added sugar, putting them at risk for poor health, childhood obesity, and chronic, diet-related diseases as adults (Nielsen et al., 2002). …
Utilizing Amr Surveillance Data To Analyze Trends In Escherichia Coli Antibiotic Resistance Levels In The South African Provinces Of Gauteng And The Eastern Cape, Celia Maris
Scripps Senior Theses
Antimicrobial resistant bacterial pathogens pose an ongoing threat to universal public health by causing more severe manifestations of infectious diseases, leading to an increase in healthcare expenditures and higher global mortality rates. Therefore, developing strategies to combat bacterial antimicrobial resistance (AMR) is vital for the future of human health. One promising strategy is through the utilization of AMR surveillance programs. This study focused on using AMR surveillance data from South Africa to analyze changes in Escherichia coli resistance levels to numerous antibiotics between January 2012 and December 2022 in Gauteng Province and the Eastern Cape Province. The study aimed to …
Transcranial Direct Current Stimulation (Tdcs) To Improve Lower Limb Motor Recovery Following Stroke: A Review And Study Proposal, Jessica Fantz-Sands
Transcranial Direct Current Stimulation (Tdcs) To Improve Lower Limb Motor Recovery Following Stroke: A Review And Study Proposal, Jessica Fantz-Sands
Scripps Senior Theses
Strokes are the result of restricted blood flow to particular areas of the brain classified by their cause. The neural damage they cause are of growing concern as the number of young adults experiencing strokes has increased by 11% in the last decade. Following stroke, there is an imbalance of inhibitory and excitatory neuronal activity, and disruption of neural networks. These changes lead to neuronal death and loss of synaptic connections that, depending on which part of the brain is affected, result in behavioral deficits such as weakness, limb hemiparesis, and loss of coordination, as well as speech and cognitive …
The Role Of Herbal Medicines In Central American Indigenous Communities; Improving Accessibility To Type 2 Diabetes Mellitus Treatment, Sarai Ortega
CMC Senior Theses
Indigenous communities in Central America have used various plant medications to treat illnesses and diseases for centuries. Clinicians must consider improving traditional healthcare methods that are intrinsic to indigenous communities in order to increase access to effective treatments, particularly for diseases that these communities are more at risk for. This work aims to propose a method to identify whether traditional preparations of five plants (Anacardium occidentale L., Hamelia patens Jacq., Momordica charantia L, Neurolaena lobota L. R. Br. Ex Cass., and Tecoma stans L. juss. ex Kunth) can reduce blood glucose levels in rats with type two diabetes. Additionally, …
The Impact Of Sugar Sweetened Beverages (Ssbs) Taxes On Consumption And Health Outcomes In Latinx Youth Residing In Los Angeles County, Jacquelyn Campos-Araujo
The Impact Of Sugar Sweetened Beverages (Ssbs) Taxes On Consumption And Health Outcomes In Latinx Youth Residing In Los Angeles County, Jacquelyn Campos-Araujo
Pitzer Senior Theses
This proposed research study aims to investigate whether the implementation of sugar-sweetened beverage (SSB) taxes will lead to reduced consumption and improved health outcomes in the Latinx youth population residing in Los Angeles County. The study will utilize a mixed-methods design, including a baseline survey and health examination, the implementation of SSB taxes, and a follow-up survey and health examination. The expected results suggest a statistically significant reduction in SSB consumption and improved glycemic control following the implementation of the SSB taxation intervention. However, I predict a slight decrease in the number of participants with dental caries, indicating that further …
Analysis Of Biologically Effective Dose For Retroactive Yttrium-90 Trans-Arterial Radioembolization Treatment Optimization, Mj Lindsey
CMC Senior Theses
Trans-arterial radioembolization (TARE) is a protracted modality of radiation therapy where radionuclides labeled with Yttrium-90 (90Y) are inserted inside a patient's hepatic artery to treat hepatocellular carcinoma (HCC). While TARE has been shown to be a clinically effective and safe treatment, there is little understanding of the radiobiological relationship between absorbed dose and tissue response, and thus there is no dosimetric standard for treatment planning. The Biologically Effective Dose (BED) formalism, derived from the Linear-Quadratic model of radiobiology, is used to weigh the absorbed dose by the time pattern of delivery. BED is a virtual dose that can …
Movement As Medicine: Dance/Movement Therapy For Individuals With Autism, Parkinson’S Disease, And Cancer, Alessia Zanobini
Movement As Medicine: Dance/Movement Therapy For Individuals With Autism, Parkinson’S Disease, And Cancer, Alessia Zanobini
CMC Senior Theses
Dance/movement therapy (D/MT) is the psychotherapeutic use of expressive, creative movement to support holistic well-being. D/MT views the human being as a single body-mind unit and movement as a manifestation of life experiences. While typically practiced as a mental health intervention, D/MT can be adapted for a variety of populations. This thesis evaluates scientific data for the non-traditional use of D/MT for three conditions: autism, Parkinson’s disease, and cancer. For individuals on the autism spectrum, D/MT can strengthen attunement skills, provide creative communication outlets, and relieve harmful physical manifestations of autism. For individuals with Parkinson’s disease, D/MT can simultaneously ease …
Stem Education And Retention For Black Women Using High-Impact Practices: Historically Black Colleges And Universities Vs. Predominantly White Liberal Arts Colleges, Annette Njei
CMC Senior Theses
Black women are significantly underrepresented within the fields of science, technology, engineering, and mathematics (STEM). To address this, the Association of American Colleges & Universities crafted ten high-impact practices to increase student engagement and promote retention. This research paper examines how three specific high-impact practices (learning communities, mentoring, and undergraduate research experience) are utilized in STEM education.This research paper explores and compares the best high impact approaches that successfully teach and retain Black women within the various fields of STEM within the differing academic environments of historically Black colleges & universities ( HBCUs) and predominantly white liberal art colleges (PWLACs). …
Treatment Of Anxiety By Transcutaneous Vagus Nerve Stimulation: A Retrospective Chart Review, Rhea Gandhi
Treatment Of Anxiety By Transcutaneous Vagus Nerve Stimulation: A Retrospective Chart Review, Rhea Gandhi
CMC Senior Theses
Surgical vagus nerve stimulation (VNS) was FDA cleared for depression (2005) and epilepsy. (1997). In the surgical procedure, a pacemaker is implanted below the collarbone (clavicle) and connected to the vagus nerve in the neck. Transcutaneous vagus nerve stimulation (tVNS) is a non-surgical alternative to VNS and there is evidence supporting its effectiveness for several conditions. Advantages include lower cost and fewer adverse side effects.
Anxiety is tied to excess or unopposed sympathetic nervous system activity, while the parasympathetic nervous system, especially the vagus nerve, is relatively underactive. This study aimed to investigate a potential impact of regular tVNS stimulation …
Visualization And Characterization Of The Immunological Synapse Between Chlorotoxin Chimeric Antigen (Cltx-Car) Redirected T Cells And Targeted Glioblastoma Tumors, Arianna Livi
CMC Senior Theses
Chimeric Antigen Receptor T (CAR-T) cells have demonstrated anti-tumor activity against aggressive and invasive cancers such as glioblastoma (GBM); however, clinical response rates remain low in clinical trial studies. Tumor heterogeneity and tumor microenvironment conditions pose significant challenges for treatment of GBM, thus continuous optimization of CAR-T cell therapies and identification of novel, widely expressed, and highly specific GBM antigens are vital to better patient outcomes. A newly developed CAR-T cell construct incorporating chlorotoxin (CLTX) as the targeting domain exhibited broad GBM-targeting capabilities and elicited potent cytotoxic effects during preclinical studies and is currently being tested in a phase I …
Investigation Into The Potential For Acquired Cross Tolerances Of Amphetamines, Benjamin Weldon
Investigation Into The Potential For Acquired Cross Tolerances Of Amphetamines, Benjamin Weldon
CMC Senior Theses
In the United States, the treatment of ADHD through use of psychostimulants in adolescents is a growing reality that many people know today and many more will know in the coming years. Although the effectiveness of psychostimulants is a known asset, the benefits of these medications may not be a permanent solution, suggesting not only the presence of a tolerance build up, but as many stimulants are prescribed in a joint effort to combat ADHD, a possible cross tolerance between two prescribed medications. There are minimal studies published that have addressed the topic of cross stimulation tolerance buildup between prescription …