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Full-Text Articles in Medicine and Health Sciences
Effect Of Sorafenib On Human Colon Cancer Cells, Marwa Al Hassan, Farah Reda, Ali Baltaji, Julnar Usta, Jamilah Borjac
Effect Of Sorafenib On Human Colon Cancer Cells, Marwa Al Hassan, Farah Reda, Ali Baltaji, Julnar Usta, Jamilah Borjac
BAU Journal - Health and Wellbeing
ABSTRACT: Sorafenib, a kinase inhibitor, is among the approved drugs for the treatment of radioactive iodine resistant thyroid carcinoma, primary kidney and liver cancers. Reported targets of Sorafenib include VEGFR, Raf family, and PDGFR belonging to the general class of tyrosine kinases. Blocking growth signals in kidney and breast cancers underlie one of the mechanisms of Sorafenib antitumor effects’ leading to cell death. We hereby examine the effect of Sorafenib on human colon carcinoma cell-line HCT116. We also investigate the possible role of p53 in mediating this effect using mutant HCT116 p53-/- cells. Cultured wild and mutant cells are treated …
The Curative Effects Of Dietary Yeast Beta-1,3/1,6-Glucan On Oxidative Stress And Apoptosis In Laying Quails (Coturnix Coturnix Japonica) Exposed To Lead, İsmai̇l Seven, Pinar Tatli Seven, Seda İflazoğlu Mutlu, Gözde Arkali, Nurgül Bi̇rben, Aslihan Sur Arslan, Mesut Aksakal
The Curative Effects Of Dietary Yeast Beta-1,3/1,6-Glucan On Oxidative Stress And Apoptosis In Laying Quails (Coturnix Coturnix Japonica) Exposed To Lead, İsmai̇l Seven, Pinar Tatli Seven, Seda İflazoğlu Mutlu, Gözde Arkali, Nurgül Bi̇rben, Aslihan Sur Arslan, Mesut Aksakal
Turkish Journal of Veterinary & Animal Sciences
The objective of this study was to investigate the effects of supplementation of beta-glucan to the basal diet of laying quails exposed to lead (Pb) toxicity. A total of 112 birds were randomly divided into 4 groups. The first group was fed a corn-soybean based basal diet without any supplementation (control). The second (Pb) and third (beta-glucan) groups were supplemented with 100 mg/kg of Pb (as Pb acetate) and 100 mg/kg of beta-glucan, respectively. The fourth group (Pb + beta-glucan) was fed a basal diet supplemented with 100 mg/kg of Pb and 100 mg/kg of beta-glucan. It was determined that …
Effects Of Feed Restriction On Histopathological Changes Associated With Whitestriping And Wooden Breast Myopathies In Pectoralis Major Muscle And Meat Qualitycharacteristics In Broiler Chickens, Hayri̇ye Değer Oral Toplu, Ni̇hat Toplu, Ahmet Nazligül, Mehmet Kaya, Ayşe Nur Akkoç
Effects Of Feed Restriction On Histopathological Changes Associated With Whitestriping And Wooden Breast Myopathies In Pectoralis Major Muscle And Meat Qualitycharacteristics In Broiler Chickens, Hayri̇ye Değer Oral Toplu, Ni̇hat Toplu, Ahmet Nazligül, Mehmet Kaya, Ayşe Nur Akkoç
Turkish Journal of Veterinary & Animal Sciences
The aim of this study was to investigate the effects of feed restriction on histopathological changes associated with white striping and wooden breast myopathies in pectoralis major muscle and meat quality characteristics in broiler chickens. In total, 600 male broiler chicks were randomly divided into five groups with 8 replicate pens (15 chicks/pen). Treatments consisted of control, treatment 1 (T1), treatment 2 (T2), treatment 3 (T3) and treatment 4 (T4). Control group was fed ad libitum throughout experimental period. T1 and T2 groups received feed as 80% and 70% of amount received by the control group from 11 to 24 …