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Articles 1 - 11 of 11
Full-Text Articles in Medicine and Health Sciences
Generation Of A More Immunogenic Fh Vlp Platform To Support Covid-19 Vaccine Development, Jewel E. Voyer, Xinyuan Chen Phd.
Generation Of A More Immunogenic Fh Vlp Platform To Support Covid-19 Vaccine Development, Jewel E. Voyer, Xinyuan Chen Phd.
Senior Honors Projects
The SARS-CoV-2 based pandemic has seen almost a million deaths in just the United States according to the CDC. This number is due to the increase of variants of COVID-19, therefore calling a demand in vaccine production. Vaccine adjuvants and carriers have been studied to increase the immunogenicity and safety of a variety of immunizations. Flagellin fused Hepatitis B core (FH) virus like particles (VLP) has been studied to have beneficial effects of TLR5, IL6 levels, and lack of body temperature rise in murine study. The FH platform also provides an improvement from its predecessors FljB alone which is a …
Assessment Of The University Of Rhode Island's Dining Halls And Student Perceptions Of On-Campus Dining, Maria Cherry
Assessment Of The University Of Rhode Island's Dining Halls And Student Perceptions Of On-Campus Dining, Maria Cherry
Senior Honors Projects
University dining halls are understudied food environments that affect student diet quality. This study (1) assessed dining hall offerings at the University of Rhode Island (URI) using the Partnership for a Healthier America’s Healthier Campus Initiative (PAHA) criteria for healthier campus food environments and (2) evaluated student perceptions of the dining hall through a campus-wide survey (n=165). We evaluated breakfast, lunch, and dinner using spring cycle menus (16 weeks in 2019 and 4 in 2021) from two full-service dining halls totaling 29 meals in 2019, and 84 meals in 2021 to determine adherence with PAHA criteria for availability of: 1) …
Integration Of Medicinal Fungi Into The Heber W. Youngken Jr. Medicinal Garden, Anthony Makashov
Integration Of Medicinal Fungi Into The Heber W. Youngken Jr. Medicinal Garden, Anthony Makashov
Senior Honors Projects
The Heber W. Youngken Jr. Medicinal Garden is a one-of-a-kind resource that houses close to 300 medicinal plants and is filled to the brim with educational opportunities. For the College of Pharmacy, this garden has been the centerpiece of many classes taught here at the University of Rhode Island and has roots as a physical teaching space. While the garden contains a plethora of plant species, medicinal fungi have yet to have been included in the garden, despite their relevance as both sources of pharmaceutical drug discovery and as natural products with inherent physiological benefits themselves. The purpose of my …
The Association Between Type-2 Diabetes Pathophysiology & Exercise Adherence, Sydney Raymond
The Association Between Type-2 Diabetes Pathophysiology & Exercise Adherence, Sydney Raymond
Senior Honors Projects
According to the American Diabetes Association, 1 in 3 Americans will be diagnosed with diabetes. While some of these individuals will be prescribed medications as part of their treatment, most will also be advised to begin an exercise program to assist with blood glucose control. Additionally, while regular exercise is associated with lower HbA1C and decreased insulin/medication dependence, it is estimated that only about half of those diagnosed with diabetes will adhere to their exercise plans. Social, psychological, and physiological factors all play roles in affecting ones ability to adhere to an exercise regiment, and individuals with Type 2 Diabetes …
The Impact Of Stress On Diet, Sleep, And Exercise Amongst College Students, Jessica Rizzo
The Impact Of Stress On Diet, Sleep, And Exercise Amongst College Students, Jessica Rizzo
Senior Honors Projects
Stress is something that everyone faces in their lifetime and has an everlasting impact on their health. College students face high levels of stress throughout the semester, but how is that impacting their behavior? I conducted a survey alongside Dr. Melanson, a professor in the Department of Nutrition and Food Sciences, to see just how college students are reacting to stress. The survey was circulated to different departments and classes to achieve a widespread collection of data. The survey remained completely anonymous and posed questions about eating, exercise, and sleep habits, along with questions on demographics and stress levels. Our …
Acute Promyelocytic Leukemia: A Case Study Correlating Cytogenetic Abnormality With Prognosis, Alyssa Lamond, Theresa Tellier-Castellone
Acute Promyelocytic Leukemia: A Case Study Correlating Cytogenetic Abnormality With Prognosis, Alyssa Lamond, Theresa Tellier-Castellone
Senior Honors Projects
Advancements in medical technology today have positively impacted the diagnosis, treatment, and prognosis of cancers. Particularly acute promyelocytic leukemia (APL) has completely improved from having the poorest prognosis to one of the best. Acute promyelocytic leukemia is a malignant disease of hematopoietic tissue classified by WHO as leukemia with >20% blasts from the myeloid lineage, specifically promyelocytes. Determined in 1976, FAB classified AML subtypes M1-M7, with APL being M3. Specific characteristics classify the subtype of AML, with each resulting from a different genetic abnormality. The focus of APL diagnosis, treatment, and prognosis occurs around the known PML-RARα fusion gene. Flow …
Mala Lā’Au Lapa’Au: Preserving The Hawaiian ‘Āina And Mo’Omehue, Sandra Fogg
Mala Lā’Au Lapa’Au: Preserving The Hawaiian ‘Āina And Mo’Omehue, Sandra Fogg
Senior Honors Projects
The study of medicinal plants in the western world tends to focus on the isolation and elucidation of natural products that have bioactive characteristics and potential for pharmaceutical formulation. However, the utilization of medicinal plants in cultures that still practice ancient medicine, such as Hawai’i and other Pacific Island nations, involves the use of whole plant parts in conjunction with spiritual rituals to heal illnesses and ailments. In order to gather a different perspective of the use of plants in medicine, a diverse investigation of “Lā’au Lapa’au,” or the Hawaiian art of healing through the use of plants and spiritual …
Zutrition: Analyzing And Evaluating Diets Fed To Captive Mammals At Capron Park Zoo, Briell M. Dzierga
Zutrition: Analyzing And Evaluating Diets Fed To Captive Mammals At Capron Park Zoo, Briell M. Dzierga
Senior Honors Projects
Zoos provide both experiential and educational opportunities for the general public to learn about animals found in a variety of habitats around the world. A successful zoo must provide a safe and enjoyable environment for the visitors, in addition to the species living within the enclosures. Animal husbandry and welfare are crucial aspects to which close attention must be paid, and zoos have a responsibility to attempt to approximate the captive species’ natural habitats and life histories. An essential part of maintaining a captive zoo animal’s health and wellbeing is providing the animal with an appropriate diet. In addition to …
Molecular Chaperone Tools For Use Against Neurodegenerative Diseases, Matthew Tinkham
Molecular Chaperone Tools For Use Against Neurodegenerative Diseases, Matthew Tinkham
Senior Honors Projects
A noted characteristic found in several neurodegenerative disorders, including Alzheimer’s Disease, Parkinson’s Disease, Huntington’s Disease and bovine spongiform encephalopathy, is the accumulation of amyloid plaques in the brain. Amyloid plaques contain deposits of fibrillar aggregates of misfolded proteins that disrupt normal functionality in neurons. Certain variants of these misfolded proteins are self-replicating; these self-replicating amyloids are termed prions (for infectious protein). We are interested in how protein misfolding contributes to amyloid formation and how molecular chaperone proteins can change the formation of amyloid deposits. Chaperone proteins function by catalyzing the proper folding of other proteins, the refolding of misfolded proteins, …
Hydra Vulgaris As A High Throughput Invertebrate For Anti-Epilepsy Drugs, Bianca Marie Lauro
Hydra Vulgaris As A High Throughput Invertebrate For Anti-Epilepsy Drugs, Bianca Marie Lauro
Senior Honors Projects
No abstract provided.
A Comparison Of Pyronin Y-Methyl Green Stain And Methylene Blue Stain For Somatic Cell Count In Sheep Milk, Emily Mirek, Stacey O’Donnell
A Comparison Of Pyronin Y-Methyl Green Stain And Methylene Blue Stain For Somatic Cell Count In Sheep Milk, Emily Mirek, Stacey O’Donnell
Senior Honors Projects
Somatic cell count is a key method used to evaluate the quality of milk in today’s growing dairy sheep industry. Somatic cells are body cells, primarily the white blood cells, found in a milk sample. If an infection such as mastitis is present, the number of somatic cells in the milk increases (Gonzalo, et al. 1992). Producers routinely perform somatic cell counts on cow and goat milk. For dairy cattle in the United States, the somatic cell count can not exceed 750,000 cells per milliliter, for commercial milk. For dairy goats the accepted limit is 1,000,000 cells per mL of …