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Obstacle Crossing In Healthy Young And Older Individuals, Hope M. Hanson, Ashlyn M. Jendro, Abigail C. Schmitt May 2023

Obstacle Crossing In Healthy Young And Older Individuals, Hope M. Hanson, Ashlyn M. Jendro, Abigail C. Schmitt

Health, Human Performance and Recreation Undergraduate Honors Theses

Introduction: In the United States, the average population age is rising and will continue to increase in the coming years.With an older population comes increased risk of injury associated with falls. Falls are considered a leading cause of injury and death in older individuals, and many falls are caused by body imbalance or obstacle collision due to a clearly visible stationary object (e.g., rug, chair, branch). Older adults tend to cross obstacles with increased toe clearance in order to prevent tripping, but much of what is known about obstacle crossing in older adults is limited to artificial obstacles that are …


Examining The Effects Of Oral Contraceptive Use On Thermoregulation, Whitley C. Atkins May 2022

Examining The Effects Of Oral Contraceptive Use On Thermoregulation, Whitley C. Atkins

Graduate Theses and Dissertations

Purpose: The purpose of this investigation was to evaluate the effects of combined (estradiol and progestin) monophasic oral contraceptive pill (OCP) use on thermoregulation. Further, we sought to evaluate OCP use on acute rehydration post-exercise in the heat using recommended rehydration guidelines. Methods: Twelve healthy, aerobically trained (VO2peak = 47.8 ± 4.7 mL/kg/min), long term female oral contraceptive users completed a familiarization trial and two experimental days separated by ≥ 7 days. The two experimental trials were identical except for the hormone dosing phase. One trial was completed during the third week of active pill dosing (ACT) and one during …


Implementing An Exercise Referral Scheme For Promoting Physical Activity In University Mental Health Care, Bryce Daniels May 2022

Implementing An Exercise Referral Scheme For Promoting Physical Activity In University Mental Health Care, Bryce Daniels

Graduate Theses and Dissertations

Introduction. Mental health symptoms and conditions are prevalent and increasing on college campuses with anxiety and depression having the highest increases in prevalence. Many college students are also physically inactive which is problematic as physical activity benefits mental health. Exercise referral schemes (ERS) can promote physical activity, though no studies have investigated the implementation of an ERS within a college counseling center. Purpose. The purpose of this dissertation was to investigate the implementation of an ERS for promoting physical activity in university mental health care. Methods. Study 1 used a qualitative descriptive design of 14 certified counselors to explore perceptions …


The Effects Of Water With Anti-Inflammatory Capabilities (Wac) On Circulating Inflammatory Biomarkers At Rest And Following Resistance Exercise, Brittany Martin May 2022

The Effects Of Water With Anti-Inflammatory Capabilities (Wac) On Circulating Inflammatory Biomarkers At Rest And Following Resistance Exercise, Brittany Martin

Health, Human Performance and Recreation Undergraduate Honors Theses

Purpose: To determine the effects of waters with anti-inflammatory capabilities (WAC) influence circulating inflammatory biomarkers at rest and following resistance exercise. Methods: Participants completed a heavy lifting protocol and drank water with anti-inflammatory capabilities for a total of six weeks. Blood samples were taken at different at 9 different time intervals to assess concentrations of anti-inflammatory markers and to quantify inflammatory biomarkers. Those time intervals included pre-AHREP 1 and post-AHREP 1, 24-hr post-AHREP 1, 48-hr post-AHREP 1, 3-week check-up, pre-AHREP 2, post-AHREP 2, 24-hr post-AHREP 2, and 48-hr post-AHREP 2. Background: The biomarkers that were focused on were: IL-6 …


Determining The Protocol And Testing Feasibility And Intensity Of The Burn2learn Interventions And Measures In College Students, Sarah Schwarz May 2022

Determining The Protocol And Testing Feasibility And Intensity Of The Burn2learn Interventions And Measures In College Students, Sarah Schwarz

Health, Human Performance and Recreation Undergraduate Honors Theses

High-intensity interval training(HIIT) is a time-efficient form of exercise that combines aerobic and resistance training methods. HIIT workouts have been found to improve executive functioning, therefore making it beneficial for school aged children. This study is an extension of the Burn2Learn protocols developed in Australia. The purpose of this study is to develop the protocol and testing feasibility and intensity of the Burn2Learn activities in college students, specifically comparing an exercise only (Gym) HIIT session and an exercise + cognitive activity (Brain) HIIT session. The participants of this study consisted of 15 undergrad students aged 20-22. Participants took mEMA cognitive …


Effects Of Exercise On Parkinson's Symptom Relief, Brooke Burnett May 2022

Effects Of Exercise On Parkinson's Symptom Relief, Brooke Burnett

The Eleanor Mann School of Nursing Undergraduate Honors Theses

In this review of twenty research articles, the effects of moderate exercise therapy on the symptoms of Parkinson’s Disease will be explored. Appropriate literature was located using the research question, “In older adults with a Parkinson’s Disease Diagnosis, how does moderate exercise influence the symptoms of this disease?” Twenty peer-reviewed research articles were examined for the impact of different forms of exercise on various symptoms associated with Parkinson’s. Nineteen of the articles reviewed provide substantial evidence in support of exercise therapy as a treatment option for people with Parkinson’s, and one of the articles found inconclusive evidence neither in support …


Self-Rated Function And Delayed Onset Muscle Soreness (Doms) Responses To 6-Week Supplementation With Waters With Anti-Inflammatory Capabilities (Wac), Kristin Garner May 2022

Self-Rated Function And Delayed Onset Muscle Soreness (Doms) Responses To 6-Week Supplementation With Waters With Anti-Inflammatory Capabilities (Wac), Kristin Garner

Health, Human Performance and Recreation Undergraduate Honors Theses

Introduction: Researchers have examined the effects of sedentary lifestyles on diminished health outcomes and are pleading individuals to take on a more active lifestyle to prevent these. However, initial efforts to exercise are often dampened by delayed onset muscle soreness (DOMS) and muscle fatigue. This can greatly reduce exercise adherence, making it difficult for individuals to overcome this temporary discomfort. Background: Research has extensively evaluated nonsteroidal anti-inflammatory drugs (NSAIDs) and fruits as anti-inflammatory supplementation to treat DOMS. Berry-derived essences are more highly concentrated in anti-inflammatory substances than regular fruit juices, but there is minimal research on their effects on exercise …


A Time-Course Characterization Of Muscle Function And Mitochondrial Markers During Colorectal Cancer-Induced Cachexia In Tumor-Bearing Male Mice, Ana Cabrera Ayuso Jul 2021

A Time-Course Characterization Of Muscle Function And Mitochondrial Markers During Colorectal Cancer-Induced Cachexia In Tumor-Bearing Male Mice, Ana Cabrera Ayuso

Graduate Theses and Dissertations

Cachexia is a multisystemic and multifactorial syndrome prevalent in cancer patients. It is clinically defined by involuntary loss of >5% weight in a six-month window, despite nutritional interventions. A negative energy balance characterizes cancer cachexia (CC), it is associated with weakness and fatigue in skeletal muscle. Impaired muscle function is associated with lower quality of life in cancer patients. Defects in mitochondrial function are strongly associated with muscle wasting. This study explored muscular contractile function and mitochondrial quality control (MQC) markers in soleus, gastrocnemius, and tibialis anterior (TA) muscles of C26-induced male tumor-bearing mice during a 25-day time course. It …


Relationship Between Global Cognition And Cardiovascular Risk Factors, Alexia Sebghati May 2021

Relationship Between Global Cognition And Cardiovascular Risk Factors, Alexia Sebghati

Health, Human Performance and Recreation Undergraduate Honors Theses

Alzheimer’s disease (AD) is currently affecting the lives of 5.8 million Americans and is expected to double within the next 30 years. With an aging populace of baby boomers, this will place great economic strain on the U.S. creating a burden of almost $1 trillion in healthcare costs. Currently, there is no cure for AD. However, studies report that many individuals with AD experience changes in the brain up to 10-15 years before the disease’s onset. It is imperative to detect future risk of developing AD or mild cognitive impairment (MCI) before significant cognitive changes arise. Many of the risk …


How The Covid-19 Pandemic Has Affected Physical Activity, Sleep And Mental Health In University Students, Faculty And Staff And To Examine The Relationship Between These Variables, Zachary Parisi May 2021

How The Covid-19 Pandemic Has Affected Physical Activity, Sleep And Mental Health In University Students, Faculty And Staff And To Examine The Relationship Between These Variables, Zachary Parisi

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Increased physical activity has been shown to be beneficial in decreasing stress. This project will expand on this knowledge while also studying college students, a demographic that has been less studied. This study will also examine the impact of COVID-19 on these variables. COVID-19 changed many peoples’ activities of daily life, and possibly physically activity levels, due to public health measures such as lockdowns and remote learning. Purpose: The purpose of this study is to examine how the COVID-19 pandemic has affected physical activity, sleep, and mental health in university students, faculty and staff and to examine the relationship …


Ensemble Learning With Recursive Partitioning Methods To Explore Relationships Between Mental Health And Physical Activity, Jessica Gilmore Dec 2020

Ensemble Learning With Recursive Partitioning Methods To Explore Relationships Between Mental Health And Physical Activity, Jessica Gilmore

Health, Human Performance and Recreation Undergraduate Honors Theses

Physical and mental health are imperative to maintaining a well functioning immune system, which is especially critical during a global pandemic. Moreover, physical and mental health contribute to the overall quality of life experienced by an individual. Consequently, it is important to explore factors that contribute to both physical and mental health. Physical activity has been previously shown to improve physical and mental health yet many individuals do not get enough physical activity daily. Using data collected during the larger Exercise is Medicine (EIM) study, the current study utilized ensemble learning with recursive partitioning methods to explore the relationships that …


Mitochondrial Contributions To Disuse Atrophy: Let’S Talk About Sex, Megan Rosa-Caldwell Jul 2020

Mitochondrial Contributions To Disuse Atrophy: Let’S Talk About Sex, Megan Rosa-Caldwell

Graduate Theses and Dissertations

Skeletal muscle atrophy is a hallmark of many pathologies and is associated with disease prognosis, quality of life, and mortality. Specifically, lack of contractile activity of the muscle can result in disuse-associated atrophy. Disuse-induced atrophy is a common phenomenon in intensive care unit (ICU) patients and significantly impacts patient prognosis and ability to transition of out of intensive care. However, effective therapeutics to mitigate disuse-associated atrophy do not exist, clearly demonstrating the scientific and clinical need to further understand mechanisms contributing to disuse atrophy. In particular, a significant portion of the scientific literature has utilized male models, yet there is …


Baseline Data Collection On The Overall Health Of First-Year Engineering Students At The University Of Arkansas, Braeley George May 2020

Baseline Data Collection On The Overall Health Of First-Year Engineering Students At The University Of Arkansas, Braeley George

Biomedical Engineering Undergraduate Honors Theses

Many factors contribute to college student's success both inside and outside of the classroom. Physical activity, mental health, sleep, and grit are key influences for academic achievement and retention. Exercise is Medicine (EIM) On Campus is part of a worldwide initiative through the American College of Sports Medicine that recognizes the importance of physical activity for health by both assessing and promoting physical activity to all students, faculty, and staff. The EIM survey is a tool for collecting general health information about a campus population, as it consists of questions on demographic information, health status, familial health history, diet choices, …


El Baloncesto Es Vida: A Look Into Strength And Conditioning, Physical Therapy, And Coaching During My Internship Abroad, Jessica Doublesin May 2020

El Baloncesto Es Vida: A Look Into Strength And Conditioning, Physical Therapy, And Coaching During My Internship Abroad, Jessica Doublesin

Health, Human Performance and Recreation Undergraduate Honors Theses

Introduction: An experience abroad can help a person grow in confidence and knowledge and allow them to immerse themselves in a new culture. During my time in Valencia, Spain, I was able to work at a youth basketball club, CB L’Horta Godella, alongside the club’s strength and conditioning coaches and the physical therapist and be a coach for the young athletes. The fact that I lived with a Spanish family and had an open mindset towards making friends and exploring new things allowed me to grow closer to the culture in Spain. By using my knowledge and passion for sports …


Ulnar Collateral Ligament Reconstruction With Traditional Docking Compared To Novel Surgical Techniques, Kayley D. Guy, Brendon P. Mcdermott, Kaitlin Gallagher, Tyrone Washington Dec 2019

Ulnar Collateral Ligament Reconstruction With Traditional Docking Compared To Novel Surgical Techniques, Kayley D. Guy, Brendon P. Mcdermott, Kaitlin Gallagher, Tyrone Washington

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Ulnar Collateral Ligament Reconstruction (UCLR) is a surgical procedure on one of the main ligaments that provides normal stability for the elbow joint against excessive valgus stress. Damage to this ligament is common in athletes performing overhead throwing activities, primarily baseball players, due to excessive valgus stress during the throwing motion. The most common form of treatment for this type of injury is reconstructive surgery of the ligament, especially if athletes wish to return to sport participation. This type of surgery is extremely invasive and requires extensive post-operative rehabilitation in order to facilitate return to play. To date, many …


Influence Of Heating And Biological Sex On Vascular Dysfunction Associated With Long-Duration Sitting And Standing, Aaron Richard Caldwell Aug 2019

Influence Of Heating And Biological Sex On Vascular Dysfunction Associated With Long-Duration Sitting And Standing, Aaron Richard Caldwell

Graduate Theses and Dissertations

Purpose: The purpose of these studies was to determine if arterial angulations (through sitting or standing), shear stress (through local heating), or a combination of these factors affected vascular function. Moreover, this studied estimated the magnitude of the effect that biological sex has on these vascular responses. Methods: Twenty-six healthy, young (18-40 years old) males (n=13) and females (n=13) completed two experimental trials (2-h sitting and 2-h standing). In a randomized fashion, one leg was passively heated in order to increase shear rate. Following a 48-h washout, participants returned to the laboratory to complete the other trial. Flow-mediated dilation (FMD) …


Volumetric Muscle Loss: The Role Of Physical Activity And Autologous Repair On Force Recovery And Signaling Pathways, Richard Perry May 2019

Volumetric Muscle Loss: The Role Of Physical Activity And Autologous Repair On Force Recovery And Signaling Pathways, Richard Perry

Graduate Theses and Dissertations

Volumetric muscle loss affects both military and civilian persons. The hallmark of this injury is incomplete muscle regeneration, excessive fibrosis, and chronic inflammatory signaling resulting in permanent functional loss. Since permanent functional loss drastically reduces quality of life, many studies have been conducted to improve force recovery. Current scientific literature considers a repair strategy of either devitalized scaffolds infused with growth factors or viable tissue plus activating factors to be the more promising interventions for optimal force recovery. PURPOSE The purpose of this study is to incorporate autologous repair and physical activity and observe the effects of muscle force recovery …


Comparative Plasma Proteomics In Muscle Atrophy Induced By Cancer Cachexia And Hindlimb Unloading, Kirsten Rene Dunlap May 2019

Comparative Plasma Proteomics In Muscle Atrophy Induced By Cancer Cachexia And Hindlimb Unloading, Kirsten Rene Dunlap

Graduate Theses and Dissertations

Introduction: Muscle atrophy results from a dysfunction in protein turnover that leads to loss of mass and function and occurs concurrently with multiple pathologies such as cancer and extended bed rest. Atrophy reduces overall quality of life while increasing morbidity and mortality. Currently, efficacious therapeutic interventions to treat and prevent muscle wasting in all its forms are lacking, however if conserved mechanisms can be identified between wasting conditions, this would aid in the development of multipurpose therapeutics to ameliorate this pathology. Purpose: To examine circulating factors present across atrophic pathologies. Methods: 35 male C57BL/6J mice were assigned to hindlimb unloading …


Determining The Prevalence Of Injuries, Musculoskeletal Symptoms, And Stressors In Athletic Training Students, Brett Frazier May 2019

Determining The Prevalence Of Injuries, Musculoskeletal Symptoms, And Stressors In Athletic Training Students, Brett Frazier

Health, Human Performance and Recreation Undergraduate Honors Theses

Athletic training is one of the youngest and most rapidly growing professions in the medical field. One of the most prevalent problems with this young profession is the lack of information in the literature about injury, illness, and symptom reporting throughout the course of their career. The purpose of this study was to determine the self-reported prevalence of clinical-related injury, and musculoskeletal disorders/dysfunctions in current athletic training students. I hypothesized that the low back, neck, hand, and knee would be the most frequently affected body areas. Athletic training students from the University of Arkansas were recruited to take this survey. …


The Acute Effects Of Citrulline Malate And Bonded Arginine Silicate Supplementation On Vasodilation Of Young Adults, Jeffrey Rogers May 2019

The Acute Effects Of Citrulline Malate And Bonded Arginine Silicate Supplementation On Vasodilation Of Young Adults, Jeffrey Rogers

Health, Human Performance and Recreation Undergraduate Honors Theses

Abstract

Background

Clinicians, professional athletes, and recreational athletes are interested in supplementation that up-regulates nitric oxide (NO) production in blood vessel endothelium, increasing arterial vasodilation. Benefits from these supplements include improvements in blood pressure, muscle hyperemia, and exercise performance. Citrulline Malate (CM) is a pre-workout ingredient, popular for its ability to increase exercise performance and blood serum concentrations of L-arginine, resulting in NO production. Recently, Inositol-Stabilized Arginine Silicate (ASI, Nitrosigine) has been added to many of the most popular pre-workout blends, following a group of studies showing ASI increases serum arginine and reduces post-workout muscle damage. Research has yet to …


Fitness Vs Fatness And Cardiovascular Health In Adolescents, Ashley E. Hensley May 2019

Fitness Vs Fatness And Cardiovascular Health In Adolescents, Ashley E. Hensley

Health, Human Performance and Recreation Undergraduate Honors Theses

Background: Adolescent obesity has been on the rise with studies showing obesity tracks into adulthood. Obesity is an independent risk factor for cardiovascular disease (CVD); CVD is the leading cause of adult death in the U.S. Previous research shows a strong positive relationship between physical activity (PA) and cardiovascular (CV) health even in an obese adult population. Thus, the relationship between adolescent physical fitness and lifetime risk for CVD and all-cause mortality should be investigated. Purpose: The purpose of this study is to determine associations between PA and adiposity with cardiovascular health in obese and non-obese weight adolescents, with the …


Validation Of A 5-Minute Vpc Test To Assess And Compare Cognitively Intact Individuals And Individuals With Cognitive Impairments, Spencer Smith Jan 2019

Validation Of A 5-Minute Vpc Test To Assess And Compare Cognitively Intact Individuals And Individuals With Cognitive Impairments, Spencer Smith

Graduate Theses and Dissertations

The prevalence of cognitive impairments in the older adult population is growing. Finding treatment solutions to impede a cognitive decline can possibly lead to fewer cases of mild cognitive impairment, dementia, and Alzheimer’s disease. A Visual Paired Comparison (VPC) could serve as a tool to predict, monitor, and regulate people who are susceptible to a cognitive decline. The purpose of this study was to 1) to determine the validity of the Neurotrack 5-minute VPC test with the Neurotrack 30-minute VPC test, 2) to determine the test-retest reliability of the Neurotrack 5-minute VPC test, 3) to compare Neurotrack 5-minute VPC scores …


The Effect Of Dehydration On Metabolism And Energy Substrate Utilization, Zachary Robert Lewis Dec 2018

The Effect Of Dehydration On Metabolism And Energy Substrate Utilization, Zachary Robert Lewis

Graduate Theses and Dissertations

The purpose of this study was to measure hormonal and metabolic markers in humans to see if simulating dehydration would emulate measures that are seen in prediabetic humans. 60 volunteers were divided into equal categories by sex and body mass index of normal or overweight. Participants completed two oral glucose tolerance tests (OGTT) after being intravenously infused with a isotonic or hypertonic saline solution for 120 minutes in a counter balanced order. All trials began with a euhydrated subject with a urine specific gravity (USG)


The Relationship Between Mental Health And Ultra-Running: A Case Study, Joshua Justin Cook Aug 2018

The Relationship Between Mental Health And Ultra-Running: A Case Study, Joshua Justin Cook

Graduate Theses and Dissertations

This instrumental case study sought to explore the relationship between ultra-running and mental health through the lived experiences of a single participant who self-identifies as an ultra-runner. Three research questions were used to explore this relationship; how did the individual decide to participate in ultra-running, what aspects of ultra-running impact the participant’s mental health, and how has engaging in ultra-running impacted the participant’s mental health? The case study utilized three semi-structured interviews, two participant observations, video documentary review, and journaling to answer these questions. A thematic analysis of the data revealed four essential themes; 1) Development of participation, 2) Promotes …


Determinants Of Hydration In Children: The Role Of Physical Activity And Parental Dietary Habits, Hyun-Gyu Suh Aug 2018

Determinants Of Hydration In Children: The Role Of Physical Activity And Parental Dietary Habits, Hyun-Gyu Suh

Graduate Theses and Dissertations

PURPOSE: The purpose of these studies was 1) to examine the factors that influence the water intake in children and 2) to identify the optimal time window to assess hydration status that would be equivalent to 24-hour urine sample in children. METHODS: Study 1: Data for 200 parents (age:3-13y, female:62%, BMI:28.4±7.0kg∙m-2) and 200 children (age:7.5±2.9y, female:44%, BMI:17.7±3.9kg∙m-2) were recruited. Subjects recorded their fluid and food consumption on the 2-day diary, and food data were analyzed by using the Nutrition Data System for Research (NDSR) program. Physical activity levels were assessed with the International Physical Activity Questionnaire (IPAQ). All urine samples …


The Effect Of Napping On Sleep Quality And Quantity In Healthy And Concussed Collegiate Athletes, Katie Stephenson-Brown May 2018

The Effect Of Napping On Sleep Quality And Quantity In Healthy And Concussed Collegiate Athletes, Katie Stephenson-Brown

Graduate Theses and Dissertations

Clinicians are increasingly prescribing a regulated sleep schedule to athletes post injury; however, baseline sleep habits of collegiate athletes are unknown. Moreover, the connection between napping and sleep quality and quantity has not been studied in collegiate athletes. Therefore, the purpose of this study is to investigate napping behaviors and their effects on sleep quantity and quality in concussed and non-concussed collegiate athletes. In a sample of 233 non-concussed collegiate athletes, 74% (172/233) of participants reported napping. Napping was not significantly associated with sleep quantity (χ 2 (2) = .23, p = .64) or quality (χ 2 (1) = .42, …


Survey Of Hydration Knowledge And Behavior In Youth Mountain Bike Teams, Natasha Brand May 2018

Survey Of Hydration Knowledge And Behavior In Youth Mountain Bike Teams, Natasha Brand

Graduate Theses and Dissertations

Many youth sports organizations recognize the importance of educating on hydration practices and awareness, although according to recent research current hydration education is not correlating to effective practices. PURPOSE: The purpose of this study was to assess and describe the hydration knowledge and behavior of student-athletes participating in competitive junior high and high school mountain bike teams, in order to substantiate further research. METHODS: A total of 133 male and female participants, ranging from 11-18 years were surveyed on their hydration knowledge and behavior. All participants were apparently healthy and were active members of a National Interscholastic Cycling Association (NICA) …


Disordered Eating Risk And Body Image Dissatisfaction Of Division I Male And Female Cheerleaders, Christopher Blaszka May 2018

Disordered Eating Risk And Body Image Dissatisfaction Of Division I Male And Female Cheerleaders, Christopher Blaszka

Graduate Theses and Dissertations

The sport of cheerleading is growing both in the high school and college setting, however there is little research on cheerleaders specifically, both sideline and competitive. It is clear that while this sport does not benefit from being affiliated with the NCAA, the athletes are still at large risk for disordered eating and eating disorders, and are in need of more accurate screening and prevention methods. With the lack of cheerleading studies in general, there is an even larger scarcity of studies that focus on males in cheerleading. The current study aims to fill the gap in the research regarding …


Exercise, Cognition, And The Aging Process Among Active, Competitive, And Sedentary Middle-Aged And Older Adults, Katherine Adams Dec 2017

Exercise, Cognition, And The Aging Process Among Active, Competitive, And Sedentary Middle-Aged And Older Adults, Katherine Adams

Health, Human Performance and Recreation Undergraduate Honors Theses

Purpose This study aimed to compare the cognitive measures of reaction time and dual-task performance among recreationally active, master athletes, and sedentary older adults aged 50 years or older. Methods 59 late middle-aged and older adults between the ages of 50 to 88 years old participated in reaction time and dual-task tests of which consisted of multiple trials on the same day. Subjects were placed either into the recreationally active, masters athlete, or sedentary activity level group based on the Rapid Assessment of Physical Activity (RAPA) form. For the gait speed with associated dual-task component, subjects walked 10-meters at two …


Rna Sequencing In The Development Of Cancer-Cachexia, Thomas Allen Blackwell Aug 2017

Rna Sequencing In The Development Of Cancer-Cachexia, Thomas Allen Blackwell

Graduate Theses and Dissertations

Introduction: Cancer is a major public health problem in the U.S. and the world. In 2013 there were an estimated 1,660,290 new cases of cancer in the U.S. Cancer-Cachexia (CC) is a common effect of many cancers, and is directly responsible for 20-40% of cancer-related deaths. The mechanisms that control the development of CC are not well understood. Most investigations of CC focus on the post-cachectic state and do not examine the progression of the condition. The purpose of this study was to utilize RNA sequencing to analyze transcriptomic alterations throughout the progression of CC. Methods: Lewis Lung Carcinoma cells …