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Full-Text Articles in Medicine and Health Sciences
Human Cytomegalovirus Induces Tlr4 Signaling Components In Monocytes Altering Tirap, Tram And Downstream Interferon-Beta And Tnf-Alpha Expression., Kok-Hooi Yew, Cory Carpenter, R Scott Duncan, Christopher J. Harrison
Human Cytomegalovirus Induces Tlr4 Signaling Components In Monocytes Altering Tirap, Tram And Downstream Interferon-Beta And Tnf-Alpha Expression., Kok-Hooi Yew, Cory Carpenter, R Scott Duncan, Christopher J. Harrison
Manuscripts, Articles, Book Chapters and Other Papers
Using TLR pathways, primary human cytomegalovirus (HCMV) induces innate responses including the production of inflammatory cytokines. Mounting evidence suggests that LPS recognition by TLR4/MD2/CD14 results in differential utilization of TIRAP-TRAF6 and TRAM-TRIF signaling, thereby leading to transcriptional activation of various cytokine genes. However, relative roles of the TLR4/MD2/CD14 complex and its adaptor proteins TIRAP and TRAM involved in regulating monocyte responses to HCMV are incomplete. Here, we provided evidence supporting the notion that the TLR4/MD2/CD14 complex contributes notably to HCMV-induced signaling and subsequent cytokine production in monocytes. In particular, induction of both IL-6 and IL-8 is associated with elevated TIRAP …
Advocate For Immunizations., Angela L. Myers
Advocate For Immunizations., Angela L. Myers
Manuscripts, Articles, Book Chapters and Other Papers
No abstract provided.