Open Access. Powered by Scholars. Published by Universities.®
Female Urogenital Diseases and Pregnancy Complications
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Maternal And Fetal Plasma Protein Changes In Fetal Growth Restriction, Maxim D. Seferovic
Maternal And Fetal Plasma Protein Changes In Fetal Growth Restriction, Maxim D. Seferovic
Electronic Thesis and Dissertation Repository
Fetal Growth Restriction (FGR) is caused by impaired maternal-fetal exchange of oxygen and nutrients causing fetal hypoxia and starvation. A functional failure of the placenta is the underlying cause, however the pathophysiology remains unknown. The fetus adapts by limiting growth, reducing demand for metabolic substrates. Monitoring the fetal size is the primary clinical method of FGR detection, though it does not distinguish a constitutionally small fetus from a pathological. Proteomic profiling of fetal and maternal plasma was therefore undertaken for discovery of biomarkers and pathological mechanisms. As a model of hepatic secreted fetal plasma proteins, HepG2 cell secretion changes in …