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Full-Text Articles in Medicine and Health Sciences

Hormonal And Reproductive Factors And Risk Of Glioma: A Prospective Cohort Study, Stephanie A. Navarro Silvera, Anthony B. Miller, Thomas E. Rohan Mar 2006

Hormonal And Reproductive Factors And Risk Of Glioma: A Prospective Cohort Study, Stephanie A. Navarro Silvera, Anthony B. Miller, Thomas E. Rohan

Department of Public Health Scholarship and Creative Works

The etiology of glioma, the most commonly diagnosed malignant brain tumor among adults in the United States, is poorly understood. Given the lower incidence rate of glioma in women than in men, it has been hypothesized that reproductive and hormonal factors may be involved in the etiology of glioma. We conducted a secondary analysis of data from the National Breast Screening Study, which included 89,835 Canadian women, aged 40–59 years at recruitment between 1980 and 1985. Linkages to national cancer and mortality databases yielded data on cancer incidence and deaths from all causes, respectively, with follow‐up ending between 1998 and …


Four Different Study Designs To Evaluate Vaccine Safety Were Equally Validated With Contrasting Limitations, Jason M. Glanz, David L. Mcclure, Stanley Xu, Simon J. Hambidge, Martin Lee, Margarette S. Kolczak, Ken Kleinman, John P. Mullooly, Eric K. France Jan 2006

Four Different Study Designs To Evaluate Vaccine Safety Were Equally Validated With Contrasting Limitations, Jason M. Glanz, David L. Mcclure, Stanley Xu, Simon J. Hambidge, Martin Lee, Margarette S. Kolczak, Ken Kleinman, John P. Mullooly, Eric K. France

Public Health Department Faculty Publication Series

OBJECTIVE:

We conducted a simulation study to empirically compare four study designs [cohort, case-control, risk-interval, self-controlled case series (SCCS)] used to assess vaccine safety.

STUDY DESIGN AND METHODS:

Using Vaccine Safety Datalink data (a Centers for Disease Control and Prevention-funded project), we simulated 250 case sets of an acute illness within a cohort of vaccinated and unvaccinated children. We constructed the other three study designs from the cohort at three different incident rate ratios (IRRs, 2.00, 3.00, and 4.00), 15 levels of decreasing disease incidence, and two confounding levels (20%, 40%) for both fixed and seasonal confounding. Each of the …