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Full-Text Articles in Medicine and Health Sciences
Genetic And Epigenetic Variations In Asthma And Wheeze Illnesses, Todd M. Everson
Genetic And Epigenetic Variations In Asthma And Wheeze Illnesses, Todd M. Everson
Theses and Dissertations
Asthma, a chronic respiratory condition, is common worldwide with no cure and limited effective prevention strategies. It is well recognized that asthma has a multifaceted etiology, though many of the underlying mechanisms involved in asthma development, persistence and remission are still convoluted. Epigenetic mechanisms, such as DNA methylation, regulate gene-expression but are not related to changes in the actual DNA sequence. Recently, differential patterns of DNA methylation within many genes have been associated with asthma, particularly within genes involved in the differentiation of pro-inflammatory T-helper 2 (Th2) cells. DNA methylation patterns within less known biologic pathways undoubtedly are involved in …
The Relationship Between Breastfeeding And The Development Of Asthma In Early Childhood, River Anne Pugsley
The Relationship Between Breastfeeding And The Development Of Asthma In Early Childhood, River Anne Pugsley
Theses and Dissertations
Purpose: Asthma can have significant adverse effects on the health and quality of life of children, and the prevalence of this condition continues to rise. Breastfeeding may protect against asthma, but some uncertainty remains. The purpose of this study was to further examine the relationship between breastfeeding and the risk of developing asthma in early childhood. Methods: Data were collected from the State and Local Area Integrated Telephone Survey: National Survey of Children's Health, 2003. The study population consisted of 33,315 children ages 0 to 5 years. Prevalence rates of asthma and breastfeeding ,were calculated, as were crude and Mantel-Haenszel …