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Full-Text Articles in Medicine and Health Sciences
Association Of Adaptive Early Phase Study Design And Late Phase Study Results In Oncology, Donna Elise Levy
Association Of Adaptive Early Phase Study Design And Late Phase Study Results In Oncology, Donna Elise Levy
Walden Dissertations and Doctoral Studies
This quantitative study assessed the association of the design methods used for early phase oncology studies (adaptive versus traditional) and the outcome of late stage clinical trials. Differences by cancer type and by drug classification were also assessed. The theoretical and conceptual frameworks used were the general systems theory and the design and evaluation of complex interventions, respectively. Units of analysis were individual oncology studies in the ClinicalTrials.gov database and Bayesian logistic modeling was applied on a random sample of 381 studies initiated after November 1999 to December 2016. When assessing study design and outcome, there were lower odds of …
Leptin Level Variance In Adults With And Without Cancer, Vilisa Chatman-Terry
Leptin Level Variance In Adults With And Without Cancer, Vilisa Chatman-Terry
Walden Dissertations and Doctoral Studies
Abstract
In 2018, health statistics revealed that, despite the many preventive measures established,
cancer was the second leading cause of death in the United States and the leading cause
of death in 22 states, exceeded only by heart disease. With obesity/leptin levels reaching
pandemic levels worldwide, and cancer having a well-known association with obesity,
both chronic diseases represent a large proportion of public health challenges. Guided by
the social ecological model, the purpose of this cross-sectional, quantitative study was to
examine if a significant difference exists in leptin levels among adults with different
types of obesity-associated and common cancers and …