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Tag Snp Selection For Finnish Individuals Based On The Ceph Utah Hapmap Database, Cristen J. Willer, Laura J. Scott, Lori L. Bonnycastle

University Faculty Publications and Creative Works

The pattern and nature of linkage disequilibrium in the human genome is being studied and catalogued as part of the International HapMap Project [2003: Nature 426:789-796]. A key goal of the HapMap Project is to enable identification of tag single nucleotide polymorphisms (SNPs) that capture a substantial portion of common human genetic variability while requiring only a small fraction of SNPs to be genotyped [International HapMap Consortium, 2005: Nature 437:1299-1320]. In the current study, we examined the effectiveness of using the CEU HapMap database to select tag SNPs for a Finnish sample. We selected SNPs in a 17.9-Mb region of …