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Perioperative Beta-Blocker Therapy And Mortality After Major Noncardiac Surgery, Peter K. Lindenauer, Penelope Susan Pekow, Kaijun Wang, Dheeresh K. Mamidi, Benjamin Gutierrez, Evan M. Benjamin

Peter Lindenauer MD

Background: Despite limited evidence from randomized trials, perioperative treatment with beta-blockers is now widely advocated. We assessed the use of perioperative beta-blockers and their association with in-hospital mortality in routine clinical practice.

Methods: We conducted a retrospective cohort study of patients 18 years of age or older who underwent major noncardiac surgery in 2000 and 2001 at 329 hospitals throughout the United States. We used propensity-score matching to adjust for differences between patients who received perioperative beta-blockers and those who did not receive such therapy and compared in-hospital mortality using multivariable logistic modeling.

Results: Of 782,969 patients, 663,635 (85 percent) …

A Wintertime Study Of Pahs In Fine And Coarse Aerosols In Sa˜O Paulo City, Brazil, Paulo A. Lotufo

Paulo A Lotufo

The Polycyclic aromatic hydrocarbons PAHs (naphthalene, acenaphthylene, acenaphthene, phenanthrene, fluoranthene, pyrene, benzo(a)anthracene, chrysene, benzo(b)fluoranthene, benzo(k)fluoranthene, benzo(a)pyrene, indeno(1,2,3-cd)pyrene and benzo(ghi)perylene) concentrations in fine (PM2.5) and coarse (PM2.5–10) atmospheric particulate matter were measured at Sa˜o Paulo city, Brazil. The dominant PAHcompounds were indeno(1,2,3-cd)pyrene, benzo(ghi)perylene and benzo(b)fluoranthene for both the fractions. The calculated ratios of some specific PAHs were in close agreement with those attributed to direct emissions of car exhaust. The factor analysis for PM2.5 produced four factors: Factor 1 was attributed to diesel emissions, Factor 2 was attributed to stationary combustion source, Factor 3 was attributed to vehicular emissions and Factor …

Clinical And Radiographic Correlates Clinical And Radiographic Correlates: A Molecular Epidemiology Study, Elvin H. Geng

Elvin H Geng

No abstract provided.