Medicine and Health Sciences Commons^™

Analysis Of Genes Encoded By A Chromosomal Insert In Rickettsia Philipii, Sydney A. Wright

Honors College Theses

Background: Spotted Fever group rickettsiae are obligate intracellular arthropod-borne bacteria. Rickettsiae are globally distributed yet typically confined to the distribution of their vector(s). Rickettsia rickettsii and Rickettsia philipii are closely related human pathogens endemic to the United States and cause similar febrile illness with differing morbidity and mortality. Genomic comparison found the presence of a 19 kilobase insert containing eleven genes in Rickettsia philipii. The functions of proteins encoded by this insert are speculated to affect virulence and pathogenicity.

Materials and Methods: Bioinformatic analysis was performed to identify functional motifs in four proteins encoded by the insert. Homologous proteins …