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Full-Text Articles in Medicine and Health Sciences
Combustion-Derived Nanoparticles, The Neuroenteric System, Cervical Vagus, Hyperphosphorylated Alpha Synuclein And Tau In Young Mexico City Residents, Lilian Calderón-Garcidueñas, Rafael Reynoso-Robles, Beatriz Pérez-Guillé, Partha S. Mukherjee, Angélica Gónzalez-Maciel
Combustion-Derived Nanoparticles, The Neuroenteric System, Cervical Vagus, Hyperphosphorylated Alpha Synuclein And Tau In Young Mexico City Residents, Lilian Calderón-Garcidueñas, Rafael Reynoso-Robles, Beatriz Pérez-Guillé, Partha S. Mukherjee, Angélica Gónzalez-Maciel
Mathematics Faculty Publications and Presentations
Mexico City (MC) young residents are exposed to high levels of fine particulate matter (PM2.5), have high frontal concentrations of combustion-derived nanoparticles (CDNPs), accumulation of hyperphosphorylated aggregated α-synuclein (α-Syn) and early Parkinson's disease (PD). Swallowed CDNPs have easy access to epithelium and submucosa, damaging gastrointestinal (GI) barrier integrity and accessing the enteric nervous system (ENS). This study is focused on the ENS, vagus nerves and GI barrier in young MC v clean air controls. Electron microscopy of epithelial, endothelial and neural cells and immunoreactivity of stomach and vagus to phosphorylated ɑ-synuclein Ser129 and Hyperphosphorylated-Tau (Htau) …