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On The Fabrication And Development Of Tissue On A Chip Devices With Included Perfused Vasculatures, Usama Ismail
On The Fabrication And Development Of Tissue On A Chip Devices With Included Perfused Vasculatures, Usama Ismail
McKelvey School of Engineering Theses & Dissertations
The advent of Tissue-on-a-Chip (TiOC) devices has provided a novel way for researchers to approach biological study and drug development. As a platform that enables human in vivo conditions to be accurately replicated ex vivo, TiOC can accelerate both fundamental biological research to answer basic questions regarding tissue behavior and function (e.g., cell-cell interactions in the tumor microenvironment (TME)) and translational research that includes testing of standard and novel therapeutics. The reported work focuses on development of processes and technologies common to two classes of TiOC. The first device is a single-layer, multi-compartment microfluidic device for investigation of pancreatic …