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Full-Text Articles in Medicine and Health Sciences
Effects Of Two Inhaled Corticosteroid/Long-Acting Beta-Agonist Combinations On Small-Airway Dysfunction In Mild Asthmatics Measured By Impulse Oscillometry, Bill Diong, Kshitiz Singh, Rogelio Menendez
Effects Of Two Inhaled Corticosteroid/Long-Acting Beta-Agonist Combinations On Small-Airway Dysfunction In Mild Asthmatics Measured By Impulse Oscillometry, Bill Diong, Kshitiz Singh, Rogelio Menendez
Faculty and Research Publications
Background: We previously showed that the long-acting beta agonist (LABA) salmeterol as inhalation powder or metered-dose inhaler improves lung-function parameters assessed by impulse oscillometry (IOS) in 2- to 5-year-old children with reversible-airway disease within 15 minutes. Objective: We studied 12- to 45-year-olds with mild persistent asthma in order to compare the onset and extent of peripheral airway effects following the first dose and after 4 weeks dosing with two inhaled corticosteroid (ICS)/LABA combinations: fluticasone propionate/salmeterol 115/21 and budesonide/formoterol 160/4.5. Methods: Thirty subjects with mild persistent asthma using only an as-needed short-acting beta-agonist (albuterol) who had at least a 40% change …