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Full-Text Articles in Medicine and Health Sciences
State-Of-Art Functional Biomaterials For Tissue Engineering, Krati Sharma, Mubarak A. Mujawar, Ajeet Kaushik
State-Of-Art Functional Biomaterials For Tissue Engineering, Krati Sharma, Mubarak A. Mujawar, Ajeet Kaushik
Electrical and Computer Engineering Faculty Publications
Nanobiotechnology-enabled tissue engineering strategies have emerged as an innovative and promising technique in the field of regenerative medical science. The design and development of multifunctional smart biomaterials compatible to human physiology is crucial to achieve the required biological function with a reduced negative biological response. Several medical bioimplants have been tested to boost life expectancy and better-quality life. The concept of biocompatibility focuses on body acceptance and no harmful effects after implantation, which require shaping the properties of materials synthesis, surface functionalization, and biofunctionality. Such developed bioactive and biodegradable materials have been utilized to achieve the required function at a …
Multiferroic Coreshell Magnetoelectric Nanoparticles As Nmr Sensitive Nanoprobes For Cancer Cell Detection, Abhignyan Nagesetti, Alexandra Rodzinski, Emmanuel Stimphil, Tiffanie Stewart, Chooda Khanal, Ping Wang, Rakesh Guduru, Ping Liang, Irina U. Agoulnik, Jeffrey Horstmyer, Sakhrat Khizroev
Multiferroic Coreshell Magnetoelectric Nanoparticles As Nmr Sensitive Nanoprobes For Cancer Cell Detection, Abhignyan Nagesetti, Alexandra Rodzinski, Emmanuel Stimphil, Tiffanie Stewart, Chooda Khanal, Ping Wang, Rakesh Guduru, Ping Liang, Irina U. Agoulnik, Jeffrey Horstmyer, Sakhrat Khizroev
Electrical and Computer Engineering Faculty Publications
Magnetoelectric (ME) nanoparticles (MENs) intrinsically couple magnetic and electric fields. Using them as nuclear magnetic resonance (NMR) sensitive nanoprobes adds another dimension for NMR detection of biological cells based on the cell type and corresponding particle association with the cell. Based on ME property, for the first time we show that MENs can distinguish different cancer cells among themselves as well as from their normal counterparts. The core-shell nanoparticles are 30 nm in size and were not superparamagnetic. Due to presence of the ME effect, these nanoparticles can significantly enhance the electric field configuration on the cell membrane which serves …
Physics Considerations In Targeted Anticancer Drug Delivery By Magnetoelectric Nanoparticles, Emmanuel Stimphil, Abhignyan Nagesetti, Rakesh Guduru, Tiffanie Stewart, Alexandra Rodzinski, Piang Liang, Sakhrat Khizroev
Physics Considerations In Targeted Anticancer Drug Delivery By Magnetoelectric Nanoparticles, Emmanuel Stimphil, Abhignyan Nagesetti, Rakesh Guduru, Tiffanie Stewart, Alexandra Rodzinski, Piang Liang, Sakhrat Khizroev
Electrical and Computer Engineering Faculty Publications
In regard to cancer therapy, magnetoelectric nanoparticles (MENs) have proven to be in a class of its own when compared to any other nanoparticle type. Like conventional magnetic nanoparticles, they can be used for externally controlled drug delivery via application of a magnetic field gradient and image-guided delivery. However, unlike conventional nanoparticles, due to the presence of a non-zero magnetoelectric effect, MENs provide a unique mix of important properties to address key challenges in modern cancer therapy: (i) a targeting mechanism driven by a physical force rather than antibody matching, (ii) a high-specificity delivery to enhance the cellular uptake of …