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Full-Text Articles in Medicine and Health Sciences

Transport Barriers Influence The Activation Of Anti-Tumor Immunity: A Systems Biology Analysis, Mohammad R. Nikmaneshi, James W. Baish, Hengbo Zhou, Lance L. Munn Nov 2023

Transport Barriers Influence The Activation Of Anti-Tumor Immunity: A Systems Biology Analysis, Mohammad R. Nikmaneshi, James W. Baish, Hengbo Zhou, Lance L. Munn

Faculty Journal Articles

Effective anti-cancer immune responses require activation of one or more naïve T cells. If the correct naïve T cell encounters its cognate antigen presented by an antigen presenting cell, then the T cell can activate and proliferate. Here, mathematical modeling is used to explore the possibility that immune activation in lymph nodes is a rate-limiting step in anti-cancer immunity and can affect response rates to immune checkpoint therapy. The model provides a mechanistic framework for optimizing cancer immunotherapy and developing testable solutions to unleash anti-tumor immune responses for more patients with cancer. The results show that antigen production rate and …


Exploration Of Robotics Need In The Medical Field And Robotic Arm Operation Via Glove Control, Aditi Vijayvergia Jan 2023

Exploration Of Robotics Need In The Medical Field And Robotic Arm Operation Via Glove Control, Aditi Vijayvergia

Master’s Theses

This thesis project is an exercise in getting hands-on experience in redesigning and modifying a robotic system. It also involves understanding the current need for robotic applications in hospital settings. To achieve the above, a thorough literature review of the current state of robotics in a hospital setting was conducted. Moreover, a number of interviews with medical care professionals were completed. Three main themes were obtained from the literature review and five main themes were obtained from the interviews which will be presented in this thesis report. The next phase of the project involved redesigning a system that is composed …