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Full-Text Articles in Medicine and Health Sciences
Isotonic Designs For Phase I Trials, Denis H. Y. Leung, You-Gan Wang
Isotonic Designs For Phase I Trials, Denis H. Y. Leung, You-Gan Wang
Research Collection School Of Economics
The purpose of a phase I trial in cancer is to determine the level (dose) of the treatment under study that has an acceptable level of adverse effects. Although substantial progress has recently been made in this area using parametric approaches, the method that is widely used is based on treating small cohorts of patients at escalating doses until the frequency of toxicities seen at a dose exceeds a predefined tolerable toxicity rate. This method is popular because of its simplicity and freedom from parametric assumptions. In this paper, we consider cases in which it is undesirable to assume a …
Middlefield Open Space And Recreation Project, Center For Economic Development
Middlefield Open Space And Recreation Project, Center For Economic Development
Center for Economic Development Technical Reports
Over one thousand acres of farmland, open space, and wetlands are converted to residential or commercial development each week in New England. In Massachusetts, nearly two acres of open space land is lost to development every hour. Current development trends suggest that this building pattern, referred to as sprawl, is likely to continue into the near future. Because the negative consequences of sprawl development are highly visible, residents of Massachusetts are becoming increasingly concerned about its impact on their communities. Residents see the unique character of their communities being transformed by uncontrolled residential and commercial development. Green fields and open …
Medical Devices: A Stronghold Of The Commonwealth's Economy, Alan Clayton-Matthews
Medical Devices: A Stronghold Of The Commonwealth's Economy, Alan Clayton-Matthews
Public Policy and Public Affairs Faculty Publication Series
We benefit from medical devices throughout our lives: Prenatal development is monitored by ultrasound devices, sports injuries are diagnosed with magnetic resonance imaging and fixed with arthroscopic tools, and heart blockages are cleared with angioplasties and drug-coated stents. Devices include the simple and mundane—eyeglasses and thermometers—and stretch to the boundaries of technology—laser scalpels, needles embedded with microprocessors, MRI machines, and artificial hearts. All are products of the medical device industry. Massachusetts is one of the nation’s leading states in medical device development and production.
Clinical Significance Of Molecular Expression Profiles Of Hürthle Cell Tumors Of The Thyroid Gland Analyzed Via Tissue Microarrays, A. Hoos, A. Stojadinovic, B. Singh, M. Dudas, Denis H. Y. Leung, A. Shaha
Clinical Significance Of Molecular Expression Profiles Of Hürthle Cell Tumors Of The Thyroid Gland Analyzed Via Tissue Microarrays, A. Hoos, A. Stojadinovic, B. Singh, M. Dudas, Denis H. Y. Leung, A. Shaha
Research Collection School Of Economics
Hürthle cell tumors are rare thyroid neoplasms for which disease biology is poorly understood and diagnosis of carcinoma can be challenging. The aim of the study was to characterize molecular expression profiles of Hürthle cell tumors and to determine the clinical significance of identified phenotypes. Paraffin-embedded tissue cores of normal thyroid (n = 18), and histopathologically well-defined Hürthle cell adenomas (n = 27), Hürthle cell tumors of unknown malignant behavior (n = 7), and minimally (n = 14) and widely (n = 21) invasive Hürthle cell carcinomas were arrayed in triplicate on tissue microarrays. Expression profiles of p53, mdm-2, p21, …