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Apolipoprotein C3 Polymorphisms, Cognitive Function And Diabetes In Caribbean Origin Hispanics, Caren E. Smith, Katherine L. Tucker, Tammy M. Scott, Maria Van Rompay, Josiemer Mattei, Chao-Qiang Lai, Laurence D. Parnell, Mireia Junyent, Yu-Chi Lee, Bibiana Garcia-Bailo, Jose M. Ordovas
Apolipoprotein C3 Polymorphisms, Cognitive Function And Diabetes In Caribbean Origin Hispanics, Caren E. Smith, Katherine L. Tucker, Tammy M. Scott, Maria Van Rompay, Josiemer Mattei, Chao-Qiang Lai, Laurence D. Parnell, Mireia Junyent, Yu-Chi Lee, Bibiana Garcia-Bailo, Jose M. Ordovas
Katherine L. Tucker
Background Apolipoprotein C3 (APOC3) modulates triglyceride metabolism through inhibition of lipoprotein lipase, but is itself regulated by insulin, so that APOC3 represents a potential mechanism by which glucose metabolism may affect lipid metabolism. Unfavorable lipoprotein profiles and impaired glucose metabolism are linked to cognitive decline, and all three conditions may decrease lifespan. Associations between apolipoprotein C3 (APOC3) gene polymorphisms and impaired lipid and glucose metabolism are well-established, but potential connections between APOC3 polymorphisms, cognitive decline and diabetes deserve further attention. Methods We examined whether APOC3 single nucleotide polymorphisms (SNPs) m482 (rs2854117) and 3u386 (rs5128) were related to cognitive measures, whether …