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Full-Text Articles in Medicine and Health Sciences
The Impact Of Pulmonary Hypertension In Preterm Infants With Severe Bronchopulmonary Dysplasia Through 1 Year., Joanne M. Lagatta, Erik B. Hysinger, Isabella Zaniletti, Erica M. Wymore, Shilpa Vyas-Read, Sushmita Yallapragada, Leif D. Nelin, William E. Truog, Michael A. Padula, Nicolas F M Porta, Rashmin C. Savani, Karin P. Potoka, Steven M. Kawut, Robert Digeronimo, Girija Natarajan, Huayan Zhang, Theresa R. Grover, William A. Engle, Karna Murthy, Children's Hospital Neonatal Consortium Severe Bpd Focus Group
The Impact Of Pulmonary Hypertension In Preterm Infants With Severe Bronchopulmonary Dysplasia Through 1 Year., Joanne M. Lagatta, Erik B. Hysinger, Isabella Zaniletti, Erica M. Wymore, Shilpa Vyas-Read, Sushmita Yallapragada, Leif D. Nelin, William E. Truog, Michael A. Padula, Nicolas F M Porta, Rashmin C. Savani, Karin P. Potoka, Steven M. Kawut, Robert Digeronimo, Girija Natarajan, Huayan Zhang, Theresa R. Grover, William A. Engle, Karna Murthy, Children's Hospital Neonatal Consortium Severe Bpd Focus Group
Manuscripts, Articles, Book Chapters and Other Papers
OBJECTIVES: To assess the effect of pulmonary hypertension on neonatal intensive care unit mortality and hospital readmission through 1 year of corrected age in a large multicenter cohort of infants with severe bronchopulmonary dysplasia.
STUDY DESIGN: This was a multicenter, retrospective cohort study of 1677 infants bornChildren's Hospital Neonatal Consortium with records linked to the Pediatric Health Information System.
RESULTS: Pulmonary hypertension occurred in 370 out of 1677 (22%) infants. During the neonatal admission, pulmonary hypertension was associated with mortality (OR 3.15, 95% CI 2.10-4.73, P < .001), ventilator support at 36 weeks of postmenstrual age (60% vs 40%, P < .001), duration of ventilation (72 IQR 30-124 vs 41 IQR 17-74 days, P < .001), and higher respiratory severity score (3.6 IQR 0.4-7.0 vs 0.8 IQR 0.3-3.3, P < .001). At discharge, pulmonary hypertension was associated with tracheostomy (27% vs 9%, P < .001), supplemental oxygen use (84% vs 61%, P < .001), and tube feeds (80% vs 46%, P < .001). Through 1 year of corrected age, pulmonary hypertension was associated with increased frequency of readmission (incidence rate ratio [IRR] = 1.38, 95% CI 1.18-1.63, P < .001).
CONCLUSIONS: Infants with severe bronchopulmonary dysplasia-associated pulmonary hypertension have increased morbidity and mortality through …
The Association Between Subclass-Specific Igg Fc N-Glycosylation Profiles And Hypertension In The Uygur, Kazak, Kirgiz, And Tajik Populations, J. N. Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, J. Zhang, Hao Wang, D. Q. Zheng, X. Y. Zhang, H. L. Peng, Z. Y. Zhao, D. Liu, Yang Sun, Q. Sun, Q. H. Li, J. X. Zhang, Ming Sun, W. J. Cao, Ana Momčilović, Genadij Razdorov, L. J. Wu, Alyce Russell, Y. X. Wang, Song Manshu, Gordan Lauc, Wei Wang
The Association Between Subclass-Specific Igg Fc N-Glycosylation Profiles And Hypertension In The Uygur, Kazak, Kirgiz, And Tajik Populations, J. N. Liu, Mamatyusupu Dolikun, Jerko Štambuk, Irena Trbojević-Akmačić, J. Zhang, Hao Wang, D. Q. Zheng, X. Y. Zhang, H. L. Peng, Z. Y. Zhao, D. Liu, Yang Sun, Q. Sun, Q. H. Li, J. X. Zhang, Ming Sun, W. J. Cao, Ana Momčilović, Genadij Razdorov, L. J. Wu, Alyce Russell, Y. X. Wang, Song Manshu, Gordan Lauc, Wei Wang
Research outputs 2014 to 2021
Hypertension results from the interaction of genetic and acquired factors. IgG occurs in the form of different subclasses, of which the effector functions show significant variation. The detailed differences between the glycosylation profiles of the individual IgG subclasses may be lost in a profiling method for total IgG N-glycosylation. In this study, subclass-specific IgG Fc glycosylation profile was investigated in the four northwestern Chinese minority populations, namely, Uygur (UIG), Kazak (KZK), Kirgiz (KGZ), and Tajik (TJK), composed of 274 hypertensive patients and 356 healthy controls. The results showed that ten directly measured IgG N-glycan traits (i.e., IgG1G0F, IgG2G0F, IgG2G1FN, IgG2G1FS, …
Incidence Of Dementia In Elderly Latin Americans: Results Of The Maracaibo Aging Study, Gladys E. Maestre, Luis J. Mena, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Gloria Pino-Ramírez, Milady Urribarrí, Inara J. Chacon, Carlos A. Chavez, Luis Falque-Madrid, Ciro A. Gaona
Incidence Of Dementia In Elderly Latin Americans: Results Of The Maracaibo Aging Study, Gladys E. Maestre, Luis J. Mena, Jesus D. Melgarejo, Daniel C. Aguirre-Acevedo, Gloria Pino-Ramírez, Milady Urribarrí, Inara J. Chacon, Carlos A. Chavez, Luis Falque-Madrid, Ciro A. Gaona
School of Medicine Publications and Presentations
Introduction—There are few longitudinal studies of dementia in developing countries. We used longitudinal data from the Maracaibo Aging Study (MAS) to accurately determine the age- and sex-specific incidence of dementia in elderly Latin Americans.
Methods—The DSM IV-R was used to diagnose dementia, which was classified as Alzheimer’s disease (AD), vascular dementia (VaD), or other. Age- and sex-specific incidence was estimated as the number of new cases of dementia divided by person-years of follow-up (p-y).
Results—The incidence of all dementia diagnoses was 9.10 per 1000 p-y (95% CI 7.13–11.44; 8026 total p-y), 5.18 for AD (95% CI 3.72–7.03; …
Democratic Republic Of The Congo: Hiv/Aids, John Tworek
Democratic Republic Of The Congo: Hiv/Aids, John Tworek
Global Public Health
The Democratic Republic of the Congo faces a great number of health issues, however, one of the most prevalent diseases within the country is HIV/AIDS. An estimated 122,168 thousand cases were reported in 2015, with the total number of deaths at 19,000, in a country that has a population of 82,804,942. The research done on HIV/AIDS in The Democratic Republic of the Congo looks at the basic epidemiology of the region, how to identify the disease, and major risk factors present. Other major challenges The Democratic Republic of the Congo faces are included, as well as suggestions for preventing further …
Microcephaly, Christianne E. Albers
Microcephaly, Christianne E. Albers
Global Issues in Public Health
Microcephaly is a noncommunicable condition causing the head of an infant to be smaller than what is typical. Microcephaly can cause delays in developmental milestones and/or can cause other conditions such as epilepsy, cerebral palsy, learning disabilities, hearing loss and vision problems. Microcephaly is found more frequently in certain populations of the world than others, specifically those with an increased number of cases with Zika virus. Women need to take preventative measures to ensure their unborn child is safe from the Zika virus. The Zika virus is not the only way microcephaly can occur. Many other causes like exposure to …
Type 1 Diabetes, Dan Bornstein
Type 1 Diabetes, Dan Bornstein
Global Issues in Public Health
The aim of this research was to increase the awareness of this disease and show the range of which it travels. Type 1 Diabetes, although not as common as Type 2 Diabetes, is a very serious disease present well around the world. Between the two forms, there are nearly 1.5 million people diagnosed with diabetes each year (American Diabetes Association, 2015). Northern European countries tend to have the highest prevalence of Type 1 diabetes. Younger children on average ages of 0-14 years, are most frequently struck with this disease (American Diabetes Association, 2015). With the given amount of symptoms that …
Type 2 Diabetes, Aj Mimlitz
Type 2 Diabetes, Aj Mimlitz
Global Issues in Public Health
The purpose of this two page educational document is to inform not only educators, but also students about the description of type two diabetes and what populations are affected, the epidemiology of type 2 diabetes, including how get diagnosed and how that diagnosis will affect specific outcomes, and the solutions to how we can prevent or begin to cure type 2 diabetes. This brief project shows plenty of statistics revolving around these main points. Research shows that “type 2 diabetes already causes 5 million deaths per year, expecting to become the 7th cause of death globally by 2030” (Alidrisi & …