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Full-Text Articles in Medicine and Health Sciences
Bronchioalveolar Carcinoma In Jefferson And Mccracken Counties, Kentucky: Gender Differences In Survival., Jasneet Aneja
Bronchioalveolar Carcinoma In Jefferson And Mccracken Counties, Kentucky: Gender Differences In Survival., Jasneet Aneja
Electronic Theses and Dissertations
Bronchioalveolar carcinoma (BAC), a rare lung cancer, is more common in women, has a high proportion of non-smokers, and better survival, especially in women, than other lung cancers. Study subjects were 83 BAC patients from two Kentucky counties. Mean survival differences were compared by selected variables. The results showed better survival for females (6.5 years) than males (3.0 years, p-value 0.02); for urban (4.3 years) compared to rural residents (2.6 years, p-value 0.04); and for females with history of hysterectomy (5.1 years) compared to females without such history (3.3 years, p-value 0.02); the last finding supports a hormonal role in …
A Member Of The Novel Fikk Family Of Plasmodium Falciparum Putative Protein Kinases Exhibits Diacylglycerol Kinase Activity And Is Exported To The Host Erythrocyte, David Floyd Curtis
A Member Of The Novel Fikk Family Of Plasmodium Falciparum Putative Protein Kinases Exhibits Diacylglycerol Kinase Activity And Is Exported To The Host Erythrocyte, David Floyd Curtis
Electronic Theses and Dissertations
Plasmodium falciparum is one of four species known to cause malaria in humans and is the species that is associated with the most virulent form of the disease. Malaria causes nearly two million deaths each year, many of these occurring among children in under-developed countries of the world. One reason for this is the prevalence of drug resistant strains of malaria that mitigate the efficacy of existing drugs. Hence, the identification of a new generation of pharmacological agents for malaria is extremely urgent. The recent identification of a group of novel protein kinases within the Plasmodium falciparum genome has provided …
Retrocyclin Rc-101 Overcomes Cationic Mutations On The Heptad Repeat 2 Of Hiv-1 Gp41, Christopher Fuhrman
Retrocyclin Rc-101 Overcomes Cationic Mutations On The Heptad Repeat 2 Of Hiv-1 Gp41, Christopher Fuhrman
Electronic Theses and Dissertations
Retrocyclin RC-101, a θ-defensin with lectin-like properties, potently inhibits infection by many HIV-1 subtypes by binding to the heptad repeat (HR)-2 region of gp41 and preventing six-helix bundle formation. In the present study, we used in silico computational exploration to identify residues of HR2 that interacted with RC-101 and then analyzed the HIV-1 Sequence Database at LANL for residue variations in the HR1 and HR2 segments that could plausibly impart in vivo resistance. Docking RC-101 to gp41 peptides in silico confirmed its strong preference for HR2 over HR1, and implicated residues crucial for its ability to bind HR2. We mutagenized …