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Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Long-Term Survival After Radical Prostatectomy Compared To Other Treatments In Older Men With Local Or Regional Prostate Cancer, Liqian Liu, Ann L. Coker, Xianglin L. Du, Janice N. Cormier, Charles E. Ford, Shenying Fang
Long-Term Survival After Radical Prostatectomy Compared To Other Treatments In Older Men With Local Or Regional Prostate Cancer, Liqian Liu, Ann L. Coker, Xianglin L. Du, Janice N. Cormier, Charles E. Ford, Shenying Fang
CRVAW Faculty Journal Articles
Background
This study aimed to address long-term survival in a large population-based cohort of men with prostate cancer receiving radical prostatectomy compared to other treatments.
Methods
We studied 5,845 patients diagnosed with local/regional stage prostate cancer at age 65–74 in 1992 with comorbidity score
Results
Of 5,845 patients, 10-year all-cause survival rates were the highest for patients receiving radical prostatectomy (81.0%; 95% CI: 79.4–82.4%), followed by radical prostatectomy in combination with radiotherapy (67.6%; 62.0–72.5%), radiotherapy (60.5%; 58.3–62.6%), and were the lowest for watchful-waiting (50.7%; 47.5–53.8%). A similar pattern was found for 10-year prostate cancer-specific survivals by treatments. After adjusting for …
Application Of Prodrugs To Inflammatory Diseases Of The Gut, Helieh S. Oz, Jeffrey L. Ebersole
Application Of Prodrugs To Inflammatory Diseases Of The Gut, Helieh S. Oz, Jeffrey L. Ebersole
Center for Oral Health Research Faculty Publications
Oral delivery is the most common and preferred route of drug administration although the digestive tract exhibits several obstacles to drug delivery including motility and intraluminal pH profiles. The gut milieu represents the largest mucosal surface exposed to microorganisms with 1010-12 colony forming bacteria/g of colonic content. Approximately, one third of fecal dry matter is made of bacteria/ bacterial components. Indeed, the normal gut microbiota is responsible for healthy digestion of dietary fibers (polysaccharides) and fermentation of short chain fatty acids such as acetate and butyrate that provide carbon sources (fuel) for these bacteria. Inflammatory bowel disease (IBD) results …