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Full-Text Articles in Medicine and Health Sciences
Bacterial Lipopolysaccharides Change Membrane Fluidity With Relevance To Phospholipid And Amyloid Beta Dynamics In Alzheimer's Disease, Ian James Martins
Bacterial Lipopolysaccharides Change Membrane Fluidity With Relevance To Phospholipid And Amyloid Beta Dynamics In Alzheimer's Disease, Ian James Martins
Research outputs 2014 to 2021
Bacterial lipopolysaccharides (LPS) and their increase in plasma in individuals in the developing world has become of major concern. LPS can transform cells by their rapid insertion into cell membranes that partition into cholesterol/sphingomyelin domains. LPS alter cell phospholipid dynamics associated with the recruitment of the Alzheimer’s disease amyloid beta (Aβ) peptide with the promotion of toxic Aβ oligomer formation. The common pattern of naturally occurring phospholipids such as1-palmitoyl-2-oleolyl-phosphatidylcholine in cells confers cells with the rapid transfer of Aβ and phospholipids. Phospholipids such as dipalmitoylphosphatidylcholine (DPPC), dimyristoylphosphatidylcholine (DMPC) and dioleoylphosphatidylcholine (DOPC) are poorly transported with delayed metabolism of Aβ oligomers. …
Diet And Nutrition Reverse Type 3 Diabetes And Accelerated Aging Linked To Global Chronic Diseases, Ian James Martins
Diet And Nutrition Reverse Type 3 Diabetes And Accelerated Aging Linked To Global Chronic Diseases, Ian James Martins
Research outputs 2014 to 2021
The acceleration in the rate of chronic diseases that involve insulin resistance has become of global concern. The rate of the most prevalent chronic disease such as cardiovascular disease is linked to the metabolic syndrome, non alcoholic fatty liver disease (NAFLD) and other chronic diseases that include obesity, diabetes and neurodegenerative diseases. The gene-environment interaction in Western countries indicates that with urbanization access to food and its content may lead to induction of epigenetic alterations and identify the gene Sirtuin 1 (Sirt 1) to be responsible for the increased risk for insulin resistance and NAFLD relevant to Type 1, Type …