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Articles 1 - 24 of 24
Full-Text Articles in Medicine and Health Sciences
Ventricular Remodeling Following Infant-Pediatric Cardiac Transplantation. Does Age At Transplantation Or Size Disparity Matter?, Girish S. Shirali, F Lombano, W L. Beeson, D A. Dyar, N F. Mulla, A Khan, J K. Johnston, R E. Chinnock, S R. Gundry, A J. Razzouk
Ventricular Remodeling Following Infant-Pediatric Cardiac Transplantation. Does Age At Transplantation Or Size Disparity Matter?, Girish S. Shirali, F Lombano, W L. Beeson, D A. Dyar, N F. Mulla, A Khan, J K. Johnston, R E. Chinnock, S R. Gundry, A J. Razzouk
Manuscripts, Articles, Book Chapters and Other Papers
Early left ventricular (LV) remodeling following pediatric cardiac transplantation has not been described. To identify patterns and determinants of change in left ventricular mass and volume posttransplant, we studied 125 consecutive children who underwent cardiac transplantation between January 1, 1989 and July 31, 1993. Two-dimensional imaging-directed M-mode echocardiograms were studied weekly until 26 weeks post-transplant. LV mass and volume (indexed to BSA1.5) were measured. LV mass index increased until 3 weeks post-transplant, and then decreased. The mean decrement in LV mass index after 8 weeks post-transplant (relative to baseline) was significantly larger in patients with donor-recipient weight ratio > 1.5 compared …
Asbestos Induces Nuclear Factor Kappa B (Nf-Kappa B) Dna-Binding Activity And Nf-Kappa B-Dependent Gene Expression In Tracheal Epithelial Cells., Yvonne M. Janssen, Aaron Barchowsky, Melinda Treadwell, Kevin E. Driscoll, B T. Mossman
Asbestos Induces Nuclear Factor Kappa B (Nf-Kappa B) Dna-Binding Activity And Nf-Kappa B-Dependent Gene Expression In Tracheal Epithelial Cells., Yvonne M. Janssen, Aaron Barchowsky, Melinda Treadwell, Kevin E. Driscoll, B T. Mossman
Dartmouth Scholarship
Nuclear factor kappa B (NF-kappa B) is a transcription factor regulating expression of genes intrinsic to inflammation and cell proliferation--features of asbestos-associated diseases. In studies here, crocidolite asbestos caused protracted and dose-responsive increases in proteins binding to nuclear NF-kappa B-binding DNA elements in hamster tracheal epithelial (HTE) cells. This binding was modulated by cellular glutathione levels. Antibodies recognizing p65 and p50 protein members of the NF-kappa B family revealed these proteins in two of the DNA complexes. Transient transfection assays with a construct containing six NF-kappa B-binding DNA consensus sites linked to a luciferase reporter gene indicated that asbestos induced …
Transactivation Of The Moloney Murine Leukemia Virus And T-Cell Receptor Beta-Chain Enhancers By Cbf And Ets Requires Intact Binding Sites For Both Proteins., Wanwen Sun, Barbara J. Graves, Nancy A. Speck
Transactivation Of The Moloney Murine Leukemia Virus And T-Cell Receptor Beta-Chain Enhancers By Cbf And Ets Requires Intact Binding Sites For Both Proteins., Wanwen Sun, Barbara J. Graves, Nancy A. Speck
Dartmouth Scholarship
The Moloney murine leukemia virus (Mo-MLV) enhancer contains binding sites (LVb and LVc) for the ets gene family of proteins and a core site that binds the polyomavirus enhancer-binding protein 2/core-binding factor (cbf) family of proteins. The LVb and core sites in the Mo-MLV enhancer contribute to its constitutive activity in T cells. All three binding sites (LVb, LVc, and core) are required for phorbol ester inducibility of the Mo-MLV enhancer. Adjacent binding sites for the ets and cbf proteins likewise constitute a phorbol ester response element within the human T-cell receptor beta-chain (TCR beta) enhancer and contribute to constitutive …
Prospects For The Control Of Bolivian Hemorrhagic Fever, Paul E. Kilgore, Clarence J. Peters, James N. Mills, Pierre E. Rollin, Lori Armstrong, Ali S. Khan, Thomas G. Ksiazek
Prospects For The Control Of Bolivian Hemorrhagic Fever, Paul E. Kilgore, Clarence J. Peters, James N. Mills, Pierre E. Rollin, Lori Armstrong, Ali S. Khan, Thomas G. Ksiazek
Department of Pharmacy Practice
No abstract provided.
Are Non-Diabetic Women With Abnormal Glucose Screening Test At Increased Risk Of Pre-Eclampsia, Macrosomia And Caesarian Birth?, Khalid S. Khan, Firasat A. Hashmi, J H. Rizvi
Are Non-Diabetic Women With Abnormal Glucose Screening Test At Increased Risk Of Pre-Eclampsia, Macrosomia And Caesarian Birth?, Khalid S. Khan, Firasat A. Hashmi, J H. Rizvi
Department of Obstetrics & Gynaecology
To determine, in non-diabetic women, the relationship of abnormal glucose screening test, with the incidence of pre-eclampsia, macrosomia and caesarian delivery, from 1988-92, 5646 consecutive women attending antenatal clinic were screened with a glucose challenge test (GCT) on their first visit (usually at 16-20 weeks); those with risk factors i.e., history of unexplained perinatal loss, macrosomia or family member with diabetes and an initial abnormal screening test were rescreened at 28-32 weeks, In 482 cases the GCT was abnormal (plasma glucose value was >140 mg% 2 hours after 75g glucose challenge). Of these, 292 had one or more abnormal critical …
Director, Owcp V. Greenwich Collieries: The End Of The True Doubt Rule, Allan Brown
Director, Owcp V. Greenwich Collieries: The End Of The True Doubt Rule, Allan Brown
West Virginia Law Review
No abstract provided.
Modification Of Benefits For Claimants Under The Federal Black Lung Benefits Program, Rita A. Massie
Modification Of Benefits For Claimants Under The Federal Black Lung Benefits Program, Rita A. Massie
West Virginia Law Review
No abstract provided.
Is The Doctor Hostile--Obstructive Impairments And The Hostility Rule In Federal Black Lung Claims, Timothy F. Cogan
Is The Doctor Hostile--Obstructive Impairments And The Hostility Rule In Federal Black Lung Claims, Timothy F. Cogan
West Virginia Law Review
No abstract provided.
The Effect Of Selenium Supplementation On The Immune Response Of Mice With Experimental Chagas' Disease, Cindy Calisi, Lynette Brooks
The Effect Of Selenium Supplementation On The Immune Response Of Mice With Experimental Chagas' Disease, Cindy Calisi, Lynette Brooks
Mahurin Honors College Capstone Experience/Thesis Projects
No abstract provided.
A Change Of Il-2 And Il-4 Production In Patients With Helicobactor Pylori Infection, X. G. Fan, Javed Yakoob, X. J. Fan, P. W. N. Keeling
A Change Of Il-2 And Il-4 Production In Patients With Helicobactor Pylori Infection, X. G. Fan, Javed Yakoob, X. J. Fan, P. W. N. Keeling
Section of Gastroenterology
Helicobactor pylori is the most common cause of gastroduodenal inflammation. However, the exact immune pathogenesis is not fully understood. To look for evidence of the immunological mechanism in H. pylori associated disease, we measured cytokine interleukin-2 (IL-2) and IL-4 levels produced by peripheral blood lymphocytes (PBL) and gastric biopsies in 20 subjects with or without H. pylori infection. H. pylori can stimulate IL-2 and IL-4 production from PBL in H. pylori negative as well as H. pylori positive individuals. The spontaneous IL-2 production by PBL and gastric biopsies was greater (p < 0.0025, <0.001)in H. pylori negative individuals than that in H. pylori infected patients. Increased IL-4 levels from PBL in H. pylori infected patients were found in the presence of H. pylori (p < 0.0025). An increased spontaneous production of IL-4 from gastric biopsies was also observed in H. pylori infected patients (p < 0.025). In conclusion, an enhanced type 2 cytokine production was observed in H. pylori infected patients, which may be responsible for H. pylori chronic infection.
The Kinetic Characterization Of Mutant L289p Of Recombinant Hiv-1 Reverse Transcriptase, Tryn Thomas Stimart
The Kinetic Characterization Of Mutant L289p Of Recombinant Hiv-1 Reverse Transcriptase, Tryn Thomas Stimart
Chemistry & Biochemistry Theses & Dissertations
The Human Immunodeficiency Virus, type 1 (HIV-1) is the causative agent of the Acquired immunodeficiency Syndrome (AIDS). Currently, AIDS is the leading cause of death amongst young people in the United States. The large increase of HIV-1 infections over the past decade has spawned considerable research in fighting the spread of this disease. One area of intense HIV-1 research has focused on the enzyme Reverse Transcriptase (RT) which is an essential enzyme involved in the replication and life cycle of HIV-1. HIV-1 RT is composed of p66 and p51 subunits and is only active as a heterodimer in vivo. …
Structural Characterization Of A Novel Inhibitor Of Hiv Reverse Transcriptase (Hiv Rt), Greggory Jon Woitte
Structural Characterization Of A Novel Inhibitor Of Hiv Reverse Transcriptase (Hiv Rt), Greggory Jon Woitte
Chemistry & Biochemistry Theses & Dissertations
Human immunodeficiency virus (HIV) infections have become a leading cause of death among young people in the United States today. As the number of HIV infections increases, so too does the cost of treatment. Together, these numbers have prompted an increase in the development of pharmaceutical interventions. HIV reverse transcriptase (HIV RT) has become a suitable target for drug therapy because it is the sole enzyme responsible for HIV replication.
Fucoidan, a sulfated polysaccharide isolated from the brown algae Fucus vesiculosus, has been shown to block a variety of cell adhesion related events including metastasis. In addition, fucoidan has also …
Dynamic Diseases In Neurology And Psychiatry, John Milton, Deborah Black
Dynamic Diseases In Neurology And Psychiatry, John Milton, Deborah Black
WM Keck Science Faculty Papers
Thirty-two (32) periodic diseases of the nervous system are identified in which symptoms and/or signs recur. In 10/32, the recurrence of a symptom complex is one of the defining features of the illness, whereas in 22/32 oscillatory signs occur in the setting of an ongoing nervous system disorder. We discuss the possibility that these disorders may be dynamic diseases.
Dynamical Disease: Identification, Temporal Aspects And Treatment Strategies For Human Illness, Jacques Bélair, Leon Glass, Uwe An Der Heiden, John Milton
Dynamical Disease: Identification, Temporal Aspects And Treatment Strategies For Human Illness, Jacques Bélair, Leon Glass, Uwe An Der Heiden, John Milton
WM Keck Science Faculty Papers
Dynamical diseases are characterized by sudden changes in the qualitative dynamics of physiological processes, leading to abnormal dynamics and disease. Thus, there is a natural matching between the mathematical field of nonlinear dynamics and medicine. This paper summarizes advances in the study of dynamical disease with emphasis on a NATO Advanced Research Workshop held in Mont Tremblant, Quebec, Canada in February 1994. We describe the international effort currently underway to identify dynamical diseases and to study these diseases from a perspective of nonlinear dynamics. Linear and nonlinear time series analysis combined with analysis of bifurcations in dynamics are being used …
Ua66/4/2 Highlights, Vol. 1, No. 2, Wku Social Work
Ua66/4/2 Highlights, Vol. 1, No. 2, Wku Social Work
WKU Archives Records
Newsletter created by and about the WKU Social Work department. Articles:
- New University Policy
- Westover, Lynn. Change is a Necessity of Life – Poem
- AIDS Education
- News from Association of Student Social Workers
- Association of Student Social Workers Potluck
- Phi Alpha News
- Field Student Spotlight – Ethan Browning & Amy Watson
Sharing Information Benefits The Meat Industry, Michael Paton
Sharing Information Benefits The Meat Industry, Michael Paton
Journal of the Department of Agriculture, Western Australia, Series 4
Cronic health problems of livestock, seldom detected on farms, reduce the efficiency of abattoirs and returns to producers. But a major project providing information to producers from abattoirs is indicating how everyone could benefit from feedback.
Smoking And Mortality From Cerebrovascular Disorders In Brazil [Portuguese]L: Comparative Study Of Capital Cities Of Metropolitan Regions, 1988 [Porug, Paulo A. Lotufo
Smoking And Mortality From Cerebrovascular Disorders In Brazil [Portuguese]L: Comparative Study Of Capital Cities Of Metropolitan Regions, 1988 [Porug, Paulo A. Lotufo
Paulo A Lotufo
The role of smoking as risk factor for stroke is controversial. An ecological design study was performed to test the association between stroke mortality and smoking in Brazil. Lung cancer mortality was used as a surrogate for smoking habit.The mortality rate for stroke (ICD-9:430-438) and lung cancer (ICD-9: 162) were determined in the following metropolitan areas: Belém, Recife, Salvador, Belo Horizonte, Rio de Janeiro, São Paulo, Curitiba and Porto Alegre for males and females between 30 years-old and 69 years-old. ANOVA test was used to compare both age-adjusted mortality rates. A negative association by ANOVA was determined between age-adjusted rates …
Tendencias De Mortalidade Por Doencas Cardiovasculares No Estado De Sao Paulo [Portuguese], Paulo A. Lotufo
Tendencias De Mortalidade Por Doencas Cardiovasculares No Estado De Sao Paulo [Portuguese], Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
Doenças Cardiovasculares: Panorama Da Mortalidade No Brasil., Paulo A. Lotufo
Doenças Cardiovasculares: Panorama Da Mortalidade No Brasil., Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.
An Overview Of The Effectiveness And Efficiency Of Hiv Prevention Programs, D. R. Holtgrave, Noreen L. Qualls, J. W. Curran, Ronald O. Valdiserri, Mary Guinan, William C. Parra
An Overview Of The Effectiveness And Efficiency Of Hiv Prevention Programs, D. R. Holtgrave, Noreen L. Qualls, J. W. Curran, Ronald O. Valdiserri, Mary Guinan, William C. Parra
Public Health Faculty Publications
Because of the enormity of the HIV-AIDS epidemic and the urgency for preventing transmission, HIV prevention programs are a high priority for careful and timely evaluations. Information on program effectiveness and efficiency is needed for decision-making about future HIV prevention priorities. General characteristics of successful HIV prevention programs, programs empirically evaluated and found to change (or not change) high-risk behaviors or in need of further empirical study, and economic evaluations of certain programs are described and summarized with attention limited to programs that have a behavioral basis. HIV prevention programs have an impact on averting or reducing risk behaviors, particularly …
Osmotic Tolerance And Volume Regulation In Cultured Cells Of The Oyster Pathogen Perkinsus Marinus, Caroline L. O'Farrell
Osmotic Tolerance And Volume Regulation In Cultured Cells Of The Oyster Pathogen Perkinsus Marinus, Caroline L. O'Farrell
Dissertations, Theses, and Masters Projects
No abstract provided.
Synergistic Effects Of Traumatic Head Injury And Apolipoprotein 4 In Patients With Alzheimer’S Disease, R. Mayeux, R. Ottman, Gladys E. Maestre, C. Ngai, M.-X. Tang, H. Ginsberg, M. Chun, B. Tycko, M. Shelanski
Synergistic Effects Of Traumatic Head Injury And Apolipoprotein 4 In Patients With Alzheimer’S Disease, R. Mayeux, R. Ottman, Gladys E. Maestre, C. Ngai, M.-X. Tang, H. Ginsberg, M. Chun, B. Tycko, M. Shelanski
School of Medicine Publications and Presentations
The apolipoprotein 4 allele increases the risk of Alzheimer’s disease (AD), but cerebral deposition of B-amyloid with age, a genetic mutation, or head injury may contribute to the pathogenesis of this disease. We examined the risks of AD associated with traumatic head injury and apolipoprotein 4 in 236 community-dwelling elderly persons. A 10-fold increase in the risk of AD was associated with both apolipoprotein 4a nd a history of traumatic head injury, compared with a two-fold increase in risk with apolipoprotein 4 alone. Head injury in the absence of an apolipoprotein 4 allele did not increase risk. These data imply …
Environment And Archaeology. Β - Visiting The Excavation Of The Neolithic Settlement At Poussi-Kalogeri (In Greek), Anastasia Tsaliki, Lilian Karali
Environment And Archaeology. Β - Visiting The Excavation Of The Neolithic Settlement At Poussi-Kalogeri (In Greek), Anastasia Tsaliki, Lilian Karali
Dr Anastasia Tsaliki, PhD
No abstract provided.
Mortality From Asthma In State Of Sao Paulo (1970-92), Paulo A. Lotufo
Mortality From Asthma In State Of Sao Paulo (1970-92), Paulo A. Lotufo
Paulo A Lotufo
No abstract provided.