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Full-Text Articles in Medicine and Health Sciences
Bacterial Lipopolysaccharides Change Membrane Fluidity With Relevance To Phospholipid And Amyloid Beta Dynamics In Alzheimer's Disease, Ian James Martins
Bacterial Lipopolysaccharides Change Membrane Fluidity With Relevance To Phospholipid And Amyloid Beta Dynamics In Alzheimer's Disease, Ian James Martins
Research outputs 2014 to 2021
Bacterial lipopolysaccharides (LPS) and their increase in plasma in individuals in the developing world has become of major concern. LPS can transform cells by their rapid insertion into cell membranes that partition into cholesterol/sphingomyelin domains. LPS alter cell phospholipid dynamics associated with the recruitment of the Alzheimer’s disease amyloid beta (Aβ) peptide with the promotion of toxic Aβ oligomer formation. The common pattern of naturally occurring phospholipids such as1-palmitoyl-2-oleolyl-phosphatidylcholine in cells confers cells with the rapid transfer of Aβ and phospholipids. Phospholipids such as dipalmitoylphosphatidylcholine (DPPC), dimyristoylphosphatidylcholine (DMPC) and dioleoylphosphatidylcholine (DOPC) are poorly transported with delayed metabolism of Aβ oligomers. …
Magnesium Therapy Prevents Senescence With The Reversal Of Diabetes And Alzheimer’S Disease, Ian James Martins
Magnesium Therapy Prevents Senescence With The Reversal Of Diabetes And Alzheimer’S Disease, Ian James Martins
Research outputs 2014 to 2021
In the current global epidemic for Non Alcoholic Fatty Liver Disease (NAFLD), diabetes and neurodegenerative diseases such as Alzheimer’s disease there has been a major interest in magnesium therapy to delay the severity of NAFLD, Type 3 diabetes and neurodegeneration in the developing and developed world. The objective of magnesium therapy is to activate the anti-aging gene Sirtuin 1 (Sirt1) to prevent cardiovascular disease, NAFLD and diabetes. Reduced consumption of nutrients such as fatty acids, glucose, cholesterol and increased magnesium consumption is closely linked to reduced bacterial lipopolysaccharides (LPS) and activation of Sirt1 relevant to active nuclear and mitochondria interactions …