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Associations Between Retinol-Binding Protein 4 And Cardiometabolic Risk Factors And Subclinical Atherosclerosis In Recently Postmenopausal Women: Cross-Sectional Analyses From The Keeps Study, Gary Huang, Dan Wang, Unab I. Khan, Irfan Zeb, Joann E. Manson, Virginia Miller, Howard N. Hodis, Matthew J. Budoff, George R. Merriam, Mitchell S. Harman, Eliot A. Brinton, Marcelle Cedars, Yali Su, Rogerio A. Lobo, Frederick Naftolin, Nanette Santoro, Hugh S. Taylor,, Rachel P. Wildman
Associations Between Retinol-Binding Protein 4 And Cardiometabolic Risk Factors And Subclinical Atherosclerosis In Recently Postmenopausal Women: Cross-Sectional Analyses From The Keeps Study, Gary Huang, Dan Wang, Unab I. Khan, Irfan Zeb, Joann E. Manson, Virginia Miller, Howard N. Hodis, Matthew J. Budoff, George R. Merriam, Mitchell S. Harman, Eliot A. Brinton, Marcelle Cedars, Yali Su, Rogerio A. Lobo, Frederick Naftolin, Nanette Santoro, Hugh S. Taylor,, Rachel P. Wildman
Department of Family Medicine
Background: The published literature regarding the relationships between retinol-binding protein 4 (RBP4) and cardiometabolic risk factors and subclinical atherosclerosis is conflicting, likely due, in part, to limitations of frequently used RBP4 assays. Prior large studies have not utilized the gold-standard western blot analysis of RBP4 levels.
Methods: Full-length serum RBP4 levels were measured by western blot in 709 postmenopausal women screened for the Kronos Early Estrogen Prevention Study. Cross-sectional analyses related RBP4 levels to cardiometabolic risk factors, carotid artery intima-media thickness (CIMT), and coronary artery calcification (CAC). Results: The mean age of women was 52.9 (± 2.6) years, and the …