Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Allergen nomenclature; allergens; bioinformatics; database; protein families. (1)
- Antibody (1)
- Childhood obesity (1)
- Cholesterol (1)
- Clostridium difficile (1)
-
- Cooking skills (1)
- Family mealtime (1)
- Feeding relationship (1)
- Food-related behavior (1)
- Grain sorghum (1)
- Immunotherapy (1)
- Physical activity (1)
- Phytosterols (1)
- Policosanols (1)
- T cell receptors; single-chain; yeast display; directed evolution; germline codon bias (1)
- Toxins (1)
- VHH (1)
- Whole kernels (1)
- Publication
-
- Department of Food Science and Technology: Faculty Publications (2)
- Food for Health: Publications (2)
- College of Education and Human Sciences: Dissertations, Theses, and Student Research (1)
- Department of Animal Science: Faculty Publications (1)
- Department of Child, Youth, and Family Studies: Faculty Publications (1)
Articles 1 - 8 of 8
Full-Text Articles in Medicine and Health Sciences
Plasticity In The Contribution Of T Cell Receptor Variable Region Residues To Binding Of Peptide-Hla-A2 Complexes, Sheena N. Smith, Daniel Sommermeyer, Kurt H. Piepenbrink, Sydney J. Blevins, Helga Bernhard, Wolfgang Uckert, Brian M. Baker, David M. Kranz
Plasticity In The Contribution Of T Cell Receptor Variable Region Residues To Binding Of Peptide-Hla-A2 Complexes, Sheena N. Smith, Daniel Sommermeyer, Kurt H. Piepenbrink, Sydney J. Blevins, Helga Bernhard, Wolfgang Uckert, Brian M. Baker, David M. Kranz
Food for Health: Publications
One hypothesis to account for MHC-restriction by T cell receptors (TCRs) holds that there are several evolutionary-conserved residues in TCR variable regions that contact MHC. While this ‘germline-codon’ hypothesis is supported by various lines of evidence, it has been difficult to test. The difficulty stems in part from the fact that TCRs exhibit low affinities for pep/MHC, thus limiting the range of binding energies that can be assigned to these key interactions using mutational analyses. To measure the magnitude of binding energies involved, here we used high affinity TCRs engineered by mutagenesis of CDR3. The TCRs included a high-affinity, MART-1/ …
Preventing Childhood Obesity: Strategies To Help Preschoolers Develop Healthy Eating Habits, Brent A. Mcbride, Dipti A. Dev
Preventing Childhood Obesity: Strategies To Help Preschoolers Develop Healthy Eating Habits, Brent A. Mcbride, Dipti A. Dev
Department of Child, Youth, and Family Studies: Faculty Publications
DURING THE PAST THREE DECADES, childhood obesity rates increased dramatically in the United States. Despite new evidence suggesting a decrease in obesity rates in 2- to 5-year-olds during recent years (Ogden et al. 2014), the prevalence of obesity in this age group remains high and is a major concern for families and early childhood educators alike.
Researchers and policy makers now recognize the critical role of early childhood teachers in shaping children's eating habits through their mealtime interactions with children (Savage, Fisher, & Birch 2007). As a result, local, state, and federal entities have introduced obesity prevention programs in early …
Choline And Choline Metabolite Patterns And Associations In Blood And Milk During Lactation In Dairy Cows, Virginia M. Artegoitia, Jesse L. Foote, Federico M. Harte, Shawn R. Campagna, Michael J. De Veth
Choline And Choline Metabolite Patterns And Associations In Blood And Milk During Lactation In Dairy Cows, Virginia M. Artegoitia, Jesse L. Foote, Federico M. Harte, Shawn R. Campagna, Michael J. De Veth
Department of Animal Science: Faculty Publications
Milk and dairy products are an important source of choline, a nutrient essential for human health. Infant formula derived from bovine milk contains a number of metabolic forms of choline, all contribute to the growth and development of the newborn. At present, little is known about the factors that influence the concentrations of choline metabolites in milk. The objectives of this study were to characterize and then evaluate associations for choline and its metabolites in blood and milk through the first 37 weeks of lactation in the dairy cow. Milk and blood samples from twelve Holstein cows were collected in …
Psychosocial Food-Related Behavior And Food Intake Of Adult Main Meal Preparers Of Food For 9-10 Year-Old Children Participating In Icook, A Five-State Childhood Obesity Pilot Prevention Study, Ashley A. Miller
College of Education and Human Sciences: Dissertations, Theses, and Student Research
Understanding adult outcomes of programs aimed at childhood obesity prevention is necessary because parents/caregivers are the most important influence on a child’s physical activity and eating habits. Based on the principles of the social cognitive theory, the iCook 4-H pilot study taught dyads consisting of 9-10 year-old children and their primary meal preparers cooking skills, healthy shopping and meal habits, and easy ways to incorporate physical activity as a family. The program took place in five states, Maine, Nebraska, South Dakota, Tennessee, and West Virginia. In each state, adult-youth dyads (n = 54) were recruited by 4-H programs and nutrition …
Characterization Of Extraction Methods To Recover Phenolic Rich Extracts From Pinto Beans That Exert High Antioxidative Activities Using Response Surface Approach, Mohammed Aldawsari
Characterization Of Extraction Methods To Recover Phenolic Rich Extracts From Pinto Beans That Exert High Antioxidative Activities Using Response Surface Approach, Mohammed Aldawsari
Department of Food Science and Technology: Dissertations, Theses, and Student Research
The pinto bean has been linked to the prevention of multiple diseases due in large part to the presence of phenolic antioxidants, which are higher in beans than in many fruits and vegetables. These components deliver health properties beyond basic nutritional characteristics by scavenging free oxygen radicals. However, these benefits are most likely due to the ability of these chemically diverse phenols to impart greater protective properties as additives or synergists acting in combination. However, optimal parameters to isolate these compounds (in terms of ratios and types) from a given natural source are not known. Without this knowledge, understanding the …
A Novel Multivalent, Single-Domain Antibody Targeting Tcda And Tcdb Prevents Fulminant Clostridium Difficile Infection In Mice, Zhiyong Yang, Diane Schmidt, Weilong Liu, Shan Li, Lianfa Shi, Jinliang Sheng, Kevin Chen, Hua Yu, Jacqueline M. Tremblay, Xinhua Chen, Kurt H. Piepenbrink, Eric J. Sundberg, Ciaran P. Kelly, Guang Bai, Charles B. Shoemaker, Hanping Feng
A Novel Multivalent, Single-Domain Antibody Targeting Tcda And Tcdb Prevents Fulminant Clostridium Difficile Infection In Mice, Zhiyong Yang, Diane Schmidt, Weilong Liu, Shan Li, Lianfa Shi, Jinliang Sheng, Kevin Chen, Hua Yu, Jacqueline M. Tremblay, Xinhua Chen, Kurt H. Piepenbrink, Eric J. Sundberg, Ciaran P. Kelly, Guang Bai, Charles B. Shoemaker, Hanping Feng
Food for Health: Publications
The incidence of Clostridium difficile infection (CDI) and associated mortality have increased rapidly worldwide in recent years. Therefore, it is critical to develop new therapies for CDI. In this study, we generated a novel, potently neutralizing, tetravalent, and bispecific antibody composed of 2 heavy-chain-only VH (VHH) binding domains against both TcdA and TcdB (designated “ABA”) that reverses fulminant CDI in mice infected with an epidemic 027 strain after a single injection of the antibody. We demonstrated that ABA bound to both toxins simultaneously and displayed a significantly enhanced neutralizing activity both in vitro and in vivo. Additionally, …
Grain Sorghum Whole Kernel Oil Lowers Plasma And Liver Cholesterol In Male Hamsters With Minimal Wax Involvement, Bo Hyun Lee, Thomas M. Carr, Curtis Weller, Susan L. Cuppett, Ismail M. Dweikat, Vicki Schlegel
Grain Sorghum Whole Kernel Oil Lowers Plasma And Liver Cholesterol In Male Hamsters With Minimal Wax Involvement, Bo Hyun Lee, Thomas M. Carr, Curtis Weller, Susan L. Cuppett, Ismail M. Dweikat, Vicki Schlegel
Department of Food Science and Technology: Faculty Publications
The lipid fraction of the grain sorghum whole kernel (GS-WK) (i.e., phytosterol rich oil or policosanol rich wax) responsible for lowering cholesterol in hamsters fed the crude lipid (wax + oil) was determined. As expected, hamsters fed an atherogenic diet for a four week period presented with higher plasma non-HDL plasma and liver esterified cholesterol than those on the low fat diet. However, the atherogenic diet containing 5% (w/w) oil significantly lowered non-HDL plasma and liver cholesterol. Although the 5% wax supplement did not affect either plasma or liver cholesterol, excreted neutral sterol and bile acid were slightly higher than …
Update Of The Who/Iuis Allergen Nomenclature Database Based On Analysis Of Allergen Sequences, C. Radauer, A. Nandy, F. Ferreira, Richard E. Goodman, J. N. Larsen, J. Lidholm, A. Pomés, M. Raulf-Heimsoth, P. Rozynek, W. R. Thomas, Heimo Breiteneder
Update Of The Who/Iuis Allergen Nomenclature Database Based On Analysis Of Allergen Sequences, C. Radauer, A. Nandy, F. Ferreira, Richard E. Goodman, J. N. Larsen, J. Lidholm, A. Pomés, M. Raulf-Heimsoth, P. Rozynek, W. R. Thomas, Heimo Breiteneder
Department of Food Science and Technology: Faculty Publications
The IUIS Allergen Nomenclature Sub-Committee, under the auspices of the World Health Organization and the International Union of Immunological Societies, maintains the systematic nomenclature of allergenic proteins and publishes a database of approved allergen names on its Web site, www.allergen.org. In this paper, we summarize updates of allergen names approved at the meetings of the committee in 2011 through 2013. These changes reflect recent progress in identification, cloning, and sequencing of allergens. The goals of this update were to increase consistency in the classification of allergens, isoallergens, and variants and in the incorporation of the evolutionary classification of proteins into …