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Full-Text Articles in Medicine and Health Sciences
The Effect Of Dietary Nitrate And Vitamin C On Endothelial Function, Oxidative Stress And Blood Lipids In Untreated Hypercholesterolemic Subjects: A Randomized Double-Blind Crossover Study, Reem Basaqr, Michealia Skleres, Rani Jayswal, D. Travis Thomas
The Effect Of Dietary Nitrate And Vitamin C On Endothelial Function, Oxidative Stress And Blood Lipids In Untreated Hypercholesterolemic Subjects: A Randomized Double-Blind Crossover Study, Reem Basaqr, Michealia Skleres, Rani Jayswal, D. Travis Thomas
Athletic Training and Clinical Nutrition Faculty Publications
BACKGROUND: Vitamin C may enhance nitric oxide (NO) production through stepwise reduction of dietary nitrate (NO3) to nitrite (NO2) to NO. The combined effect of vitamin C and NO3 supplementation is relatively unexplored in untreated hypercholesterolemia.
AIMS: We aimed to examine whether co-administration of vitamin C and nitrate for 4-weeks would improve endothelial function (primary outcome), plasma NO metabolites, oxidative stress, and blood lipids (secondary outcomes).
METHODS: Subjects 50–70 years of age with low density lipoprotein (LDL) > 130 mg/dL and RHI ≤ 2 were enrolled in this randomized double-blind crossover study. Subjects were assigned to …