Medicine and Health Sciences Commons^™

Orofacial Pigmentation In Hemodialysis Patients: A Case Control Study, Asmaa Ras, Eman Khalil, Radwa Hussein, Nevine Kheir El Din

Dentistry

ABSTRACT Introduction: Orofacial pigmented lesions are one of the most significant changes that present in patients with end-stage renal disease (ESRD), reflecting a wide range of clinical entities ranging from physiologic changes to signs of systemic disorders and even cancers. The research on oral pigmentations is limited, so it is important to pay close attention to this topic. The majority of original publications is either focused on a single lesion or are narrative reports with limited demographic information. As a result, the current study’s goal was to determine the incidence of orofacial pigmentation in ESRD patients on hemodialysis in a …

Microbial Screening Reveals Oral Site-Specific Locations Of The Periodontal Pathogen Selenomonas Noxia, Jaydene Mcdaniel, Steven Mcdaniel, Beanca Jhanine Samiano, Matthew Marrujo, Karl Kingsley, Katherine M. Howard

Dental Medicine Faculty Publications

Introduction: Selenomonas noxia (SN) is an important periodontal pathogen, associated with gingivitis and periodontitis. Many studies have found associations between SN and indicators of poor health outcomes, such as smoking, low socioeconomic status and obesity. However, less is known about the prevalence of this organism and more specifically about other oral site-specific locations that may harbor this organism. Methods: Using an existing patient repository (n = 47) of DNA isolated from saliva and other oral sites (n = 235), including the dorsum of the tongue, lower lingual incisor, upper buccal molar and gingival crevicular fluid (GCF), molecular screening for SN …

Oral Conditions In Hepatitis C Virus‐Infected Egyptian Patients: A Case‐Control Study, Asmaa Ras, Eman Khalil

Dentistry

Introduction: One of the serious public health problems nowadays is the hepatitis C virus (HCV) infection. Hepatitis C virus infection morbidity is associated with a diversity of extrahepatic disorders counting the oral cavity. Some of the oral manifestations are oral diseases like lichen planus and xerostomia and side effects of the virus therapy. The aim of this study was to evaluate and compare the oral health status, of patients with and without virus C in a sample of the Egyptian population.
Methods: Data were collected from the Gastroenterology department at Benha University. The study was designed as a case-control study; …

In Vivo Effectiveness And Safety Of Probiotics On Prophylaxis And Treatment Of Oral Candidiasis: A Systematic Review And Meta-Analysis, Lijun Hu, Mimi Zhou, Andrew L. Young, Weiwei Zhao, Zhimin Yan

All Dugoni School of Dentistry Faculty Articles

BACKGROUND: To systematically review and assess the in vivo effectiveness and safety of probiotics for prophylaxis and treating oral candidiasis.

METHODS: A literature search for studies published in English until August 1, 2018 was conducted in the following databases: PubMed, EMBASE, Cochrane Library, and Web of Science. Randomized controlled clinical trials and experimental mouse animal model studies comparing probiotics (at any dosage and in any form) with control groups (placebo, blank control or other agents) and reporting outcomes of the prophylactic and therapeutic effects were considered for inclusion. A descriptive study and, potentially, a meta-analysis were planned.

RESULTS: Six randomized …

My Preferred Pronoun Is She: Understanding Transgender Identity And Oral Health Care Needs, Diana V. Macri, Kate Wolfe

Publications and Research

This literature review summarizes current research and evidence regarding transgender persons and oral health. Methods: A search of the literature was conducted in the following databases: PubMed, Google Scholar, EBSCO Host, Science Direct, and Wiley Online Library using the keywords "transgender identity, gender non-conforming, discrimination, transition, binary systems, transgender oral cavity, transgender, transgender oral health, transgender dental health." Articles published from 2000 to 2017 in both peer-reviewed and non-peer reviewed journals, which reported information regarding the oral health status of transgender populations, were selected for review. Results: The search revealed 18 articles, only 7 of which pertained to the oral …

Adenosquamous Carcinoma Of The Tongue, Yeshwant B. Rawal, Kenneth M. Anderson

School of Dentistry Faculty Research and Publications

A 51-year-old white female presented with a painful ulcer of the left ventrolateral tongue. An incisional biopsy confirmed a diagnosis of adenosquamous carcinoma. The adenosquamous carcinoma is an uncommon malignant tumor with histopathological features of a squamous carcinoma and an adenocarcinoma. A definitive diagnosis requires histopathological examination of a deep biopsy involving the submucosal tissue. This malignant tumor shows aggressive behavior with early invasive growth and a poor prognosis. The histopathological findings and differential diagnosis of a case of adenosquamous carcinoma of the tongue are discussed.

Nlrx1 Modulates Differentially Nlrp3 Inflammasome Activation And Nf-Κb Signaling During Fusobacterium Nucleatum Infection, Shu Chen Hung, Pei Rong Huang, Cassio Luiz Coutinho Almeida-Da-Silva, Kalina R. Atanasova, Ozlem Yilmaz, David M. Ojcius

All Dugoni School of Dentistry Faculty Articles

NOD-like receptors (NLRs) play a large role in regulation of host innate immunity, yet their role in periodontitis remains to be defined. NLRX1, a member of the NLR family that localizes to mitochondria, enhances mitochondrial ROS (mROS) generation. mROS can activate the NLRP3 inflammasome, yet the role of NLRX1 in NLRP3 inflammasome activation has not been examined. In this study, we revealed the mechanism by which NLRX1 positively regulates ATP-induced NLRP3 inflammasome activation through mROS in gingival epithelial cells (GECs). We found that depletion of NLRX1 by shRNA attenuated ATP-induced mROS generation and redistribution of the NLRP3 inflammasome adaptor protein, …

Angioleiomyoma (Vascular Leiomyoma) Of The Oral Cavity, Swati Y. Rawal, Yeshwant B. Rawal

School of Dentistry Faculty Research and Publications

A 70-year-old male presented with a slow growing, dome shaped and painless mass of the hard palate. The mass was excised. Histopathological examination confirmed the diagnosis of a angioleiomyoma (vascular leiomyoma). A leiomyoma is an uncommon benign tumor of smooth muscle differentiation. True leiomyomas of the oral cavity are rare and most oral tumors are derived from the smooth muscle of walls of blood vessels. Therefore, they are called vascular leiomyomas or angioleiomyomas. Clinically, they may resemble a myriad other conditions both benign and malignant. A definitive diagnosis depends upon histopathological examination of the biopsied tissue in correlation with the …

Pseudomyogenic Hemangioendothelioma: A Vascular Tumor Previously Undescribed In The Oral Cavity, Yeshwant B. Rawal, Kenneth M. Anderson, Thomas B. Dodson

School of Dentistry Faculty Research and Publications

The pseudomyogenic hemangioendothelioma (PMH) is a low-grade malignant vascular neoplasm of different tissue planes including skin and soft tissue. Primary tumors in the skeletal muscle and bone have also been diagnosed. The PMH was introduced into the WHO classification of tumors of soft tissue and bone in 2013. This is the first description of oral involvement. A 21-year-old female presented with a 2-month old swelling of her gingiva. The swelling appeared red in color and was soft in consistency. A clinical diagnosis of a pyogenic granuloma was made and an incisional biopsy was submitted for histopathological evaluation. The lesion consisted …

S-100 Negative Granular Cell Tumor (So-Called Primitive Polypoid Non-Neural Granular Cell Tumor) Of The Oral Cavity, Yeshwant B. Rawal, Thomas B. Dodson

School of Dentistry Faculty Research and Publications

Four cases of cutaneous S-100 negative granular cell tumor were described in 1991. Until now, only 3 cases of oral involvement have been documented in English literature. Two additional cases of oral S-100 negative granular cell tumor are described. Immunohistochemical markers were applied to exclude other lesions that may show the presence of granular cells. The clinical findings were correlated with the histopathological and immunohistochemical features to arrive at the appropriate diagnosis. S-100 negative granular cell tumors are erythematous polypoid masses commonly mistaken for granulation tissue or a pyogenic granuloma. Any part of the oral cavity may be affected. Histopathologically, …

Oral Melanoma: Relevance To The Dental Team Members, Yeshwant B. Rawal, Thomas B. Dodson, Harbinder S. Bal

School of Dentistry Faculty Research and Publications

Background and Overview

Oral melanomas vary in color and morphology and resemble myriad other reactive, benign, or malignant conditions. The authors describe a case report of a patient with a primary oral melanoma that presented as a nonspecific ulcer, which showed nodal metastasis during resection.

Case Description

A 64-year-old man who was examined by his periodontist to assess implant healing had a reddish-purple ulcer of the maxillary mucosa of 3 to 4 weeks duration. The implant was placed 19 weeks earlier in the mandible. The provisional diagnosis was that this ulcer was a traumatic or inflammatory lesion. The clinician biopsied …

Contribution Of Probiotics Streptococcus Salivarius Strains K12 And M18 To Oral Health In Humans: A Review, Turner A. Stowik

Honors Scholar Theses

The overgrowth and disequilibrium of pathogenic microorganism species both native and non-native to the oral cavity can manifest into a variety of different oral diseases, pathologies, and afflictions in humans, including dental caries, gingivitis, pharyngitis, halitosis, and oral candidiasis. Two bacterial strains with clinically-significant probiotic applications in curtailing the pathogenic bacterial growth involved in these conditions are Streptococcus salivarius strain K12 and Streptococcus salivarius strain M18. To summarize the most up-to-date in vitro, in vivo, and clinical research findings, administration of these S. salivarius strains typically in the form of probiotic lozenges results in colonization, reduction in inflammatory measures, …

Oral Atypical Cellular Blue Nevus: An Infiltrative Melanocytic Proliferation, Brian S. Shumway, Yeshwant B. Rawal, Carl M. Allen, John R. Kalmar, Cynthia M. Magro

School of Dentistry Faculty Research and Publications

The atypical cellular blue nevus is an extremely rare nevomelanocytic lesion which lacks precise histologic characterization in the current literature. Given the potential for significant architectural and cytologic overlap with melanoma, further study, including molecular analysis, is needed. This is the first description of an atypical cellular blue nevus of the oral cavity.

Intraoral Phaeohyphomycosis, Yeshwant B. Rawal, John R. Kalmar

School of Dentistry Faculty Research and Publications

Phaeohyphomycosis is an infection caused by pigment-producing saprophytic fungi. Systemic infections may occur in the immunocompromised patient. Infection in healthy individuals may result in subcutaneous abscess formation. Oral lesions appear to be rare. A case of intraoral phaeohyphomycosis presenting as a well-demarcated, painful nodule of the anterior hard palate in a 12-year-old healthy male is described. The mass was excised and the diagnosis was established following histopathologic examination of the tissue.

Myopericytoma Of The Oral Cavity, Vivekanand Datta, Yeshwant B. Rawal, Harry H. Mincer, Mark K. Anderson

School of Dentistry Faculty Research and Publications

Background.

Myopericytoma is a rare mesenchymal neoplasm of pericytic cells demonstrating myoid differentiation. The lesion typically arises within the subcutaneous tissue of the extremities. We report a case that, to the best of our knowledge, is the first case of myopericytoma involving the soft tissue of the oral cavity.

Methods.

A 36-year-old woman had a 5-mm sessile, whitish-pink, firm tongue nodule. The patient underwent excisional biopsy, and histopathologic examination as well as immunohistochemical analysis were performed.

Results.

The differential diagnosis by histologic analysis included solitary fibrous tumor, myofibroma, glomus tumor, and myopericytoma. The results of immunohistochemical analysis, when combined with …

Comparison Of Accuracy Captured By Different Controlled Languages In Oral Pathology Diagnoses, Jung-Wei Chen, Catherine Flaitz, Todd Johnson

Journal Articles

This project was comparing the accuracy of capturing the oral pathology diagnoses among different coding systems. 55 diagnoses were selected for comparison among 5 coding systems. The results of accuracy in capturing oral diagnoses are: AFIP (96.4%), followed by Read 99 (85.5%), SNOMED 98 (74.5%), ICD-9 (43.6%), and CDT-3 (14.5%). It shows that the currently used coding systems, ICD-9 and CDT-3, were inadequate, whereas the AFIP coding system captured the majority of oral diagnoses. In conclusion, the most commonly used medical and dental coding systems lack terms for the diagnosis of oral and dental conditions.