The Possible Protective Role Of Vitamin E On The Induced Silver Nanoparticles Toxicity On Filiform And Circumvallate Tongue Papillae Of Albino Rats Histological And Immunohistochemical Study, Nada Tarek Zaki, Mahmoud Al Ankily, Reham Magdy Amin, Ahmed Mahmoud Halawa

Dentistry

Recently Silver nanoparticles (AgNPs) are widely used as in manufacturing of filters to purify drinking water, as a part of surgical prosthesis, splints, dental alloys and most importantly in the medical field as a bactericidal, fungicidal and as a therapeutic agent. Although these widely usage of AgNPs, can induce toxicity. to evaluate the protective role of vitamin Eon the induced silver nanoparticles toxicity on filiform and circumvallate tongue papillae of albino rats. twenty-eight male albino rats weighing 200-250 grams were divided into; the control and the experimental groups, which is subdivided into, subgroup I receiving AgNPs and subgroup II receiving …

Does Covid-19 Contribute To Development Of Neurological Disease?, Arehally M. Mahalakshmi, Bipul Ray, Sunanda Tuladhar, Abid Bhat, Shasthara Paneyala, Duraisamy Patteswari, Meena K. Sakharkar, Hamdan Hamdan, David M. Ojcius, Srinivasa R. Bolla, Musthafa M. Essa, Saravana B. Chidambaram, M. Walid Qoronfleh

All Dugoni School of Dentistry Faculty Articles

Background: Although coronavirus disease 2019 (COVID-19) has been associated primarily with pneumonia, recent data show that the causative agent of COVID-19, the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can infect a large number of vital organs beyond the lungs, such as the heart, kidneys, and the brain. Thus, there is evidence showing possible retrograde transmission of the virus from the olfactory epithelium to regions of the brain stem. Methods: This is a literature review article. The research design method is an evidence-based rapid review. The present discourse aim is first to scrutinize and assess the available literature on …

Ada News - 12/07/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Care And Maintenance Of Dental Restorations, Ibeth Erazo

Publications and Research

Contributing to the longevity of the restoration by minimizing the effects of surface corrosion, maintaining the esthetic appearance and the smooth surface characterization, and contributing to gingival health by lessening the potential for plaque retention are the principal reasons for taking care of dental restorations. However, during oral hygiene routine procedures and prevention treatments, these desired effects are not always achieved. In many cases, the restorative materials are not identified in a patient’s record leading to damage during oral hygiene performance by dental professionals. Therefore, it is important to be able to recognize the different restorative materials and employ the …

Dysphagia And Masticatory Performance As A Mediator Of The Xerostomia To Quality Of Life Relation In The Older Population., Ting-Yu Lu, Jen-Hao Chen, Je-Kang Du, Ying-Chun Lin, Pei-Shan Ho, Chien-Hung Lee, Chih-Yang Hu, Hsiao-Ling Huang

School of Public Health Faculty Publications

Background: The impact of poor oral health on older adults' quality of life is a public health problem. In this study, the mediating effects of dental status, occlusal condition, dysphagia, and masticatory performance on the association between xerostomia and oral health-related quality of life (OHRQoL) were assessed in the older adult population.Methods: Stratified cluster sampling was used to recruit 1076 community-dwelling adults aged 65 years and older from Kaohsiung, Taiwan. Community care centers were randomly selected according to their geographic classifications (urban, rural, or mountainous areas). Assessments of dental status and occlusal condition were performed by dentists. Information on demographics, …

Integrated Oral Health Teams: An Opportunity For Occupational Therapy In Primary Care, Stephanie De Sam Lazaro

Occupational Therapy Faculty Scholarship

This poster presentation identifies opportunities for the occupational therapy role within integrated pediatric healthcare teams and articulates considerations for providing healthcare services and education within an integrated pediatric healthcare team model.

Influence Of Blood Contamination On The Bond Strength And Biointeractivity Of Biodentine Used As Root-End Filling, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: To evaluate the influence of blood contamination on the bond strength and apatite forming ability of Biodentine used as root-end filling material. Methodology: Eighty (n = 80) extracted single-rooted, sound human maxillary anterior teeth were prepared and obturated. Then, the roots were resected, retrograde cavities were prepared and Biodentine was inserted as the root-end filling material. Teeth were then randomly divided into 2 equal groups (n = 40) according to the setting environment of Biodentine i.e., group A where setting took place in human blood and group B where setting took place in deionized water (control group). Teeth were …

Relation Of Oral Ulcers To Quality Of Life: A Cross-Sectional Study, Enji Ahmed, Ayat Gaml Abdelnasser, Mai Zakaria, Soheir Gafar

Dentistry

Oral ulcers affect many dental patients; impairing their lives physically, psychologically, and socially. Due to the absence of information about oral ulcers in our population, the authors undertook a pilot study to obtain a more complete picture of prevalence of oral ulcers, its probable risk factors and its burden on the quality of life. Materials and methods The authors performed a cross‑sectional study with 605 adult dental patients. All patients filled a questionnaire inquiring about the risk factors. An oral examination was performed to each participant to determine presence or absence of oral ulcers; and the type of the oral …

Dental Sealants And Restorative Treatment For First Molars Among Medicaid Enrollees, Christopher Okunseri, Brian D. Hodgson, Elaye Okunseri, Raul Garcia, Alexis D. Visotcky, Aniko Szabo

School of Dentistry Faculty Research and Publications

Objectives

To assess the association between dental sealant placement and subsequent restorative treatment of permanent first molars over time.

Methods

We analysed Wisconsin Medicaid claims data from 2001 to 2009 for children aged 6-16 years. Children entered the study cohort at age 6 and were censored if Medicaid eligibility was lost for >31 days. A fixed effects analysis via a Cox proportional hazards model, stratified by individual, was used to estimate the time-averaged and time-dependent effects of sealant placement on dental treatment defined as any restorative, endodontic or surgical procedure.

Results

A total of 185,262 children with permanent first molars …

A Dynamic Mechanical Method To Assess Bulk Viscoelastic Behavior Of The Dentin Extracellular Matrix, Yvette Alania, Mariana Cavalcante Dos Reis, Joo-Won Nam, Rasika S. Phansalkar, James Mcalpine, Shao-Nong Chen, Guido F. Pauli, Ana K. Bedran-Russo

School of Dentistry Faculty Research and Publications

Objectives

To develop a protocol for assessment of the bulk viscoelastic behavior of dentin extracellular matrix (ECM), and to assess relationships between induced collagen cross-linking and viscoelasticity of the dentin ECM.

Methods

Dentin ECM was treated with agents to induce exogenous collagen cross-linking: proanthocyanidins (PACs) from Vitis vinifera – VVe, PACs from Pinus massoniana - PMe, glutaraldehyde – (GA), or kept untreated (control). A dynamic mechanical strain sweep method was carried out in a 3-point bending submersion clamp at treatment; after protein destabilization with 4 M urea and after 7-day, 6-month, and 12-month incubation in simulated body fluid. Tan δ, …

Epidemiology Of Male Breast Cancer, Santhi Konduri, Maharaj Singh, George Bobustuc, Richard Rovin, Amin Kassam

School of Dentistry Faculty Research and Publications

Background

Due to its rarity, few studies have characterized the epidemiology of male breast cancer. The purpose of this study was to determine survival and risk factors for male breast cancer in a large U.S. population.

Methods

In this study, 19,795 male patients with breast cancer were identified from the National Cancer Database (2004–2014). Patient demographics, tumor characteristics and treatments were analyzed by using descriptive statistics. We used multivariate Cox regression and Kaplan Meier analysis.

Results

Over 10 years, the incidence of male breast cancer increased from 7.2% to 10.3%, while mortality decreased from 11% to 3.8%. Socioeconomic factors predicting …

Serum Levels Of Vitamin C And Vitamin D In A Cohort Of Critically Ill Covid-19 Patients Of A North American Community Hospital Intensive Care Unit In May 2020: A Pilot Study, Cristian Arvinte, Maharaj Singh, Paul E. Marik

School of Dentistry Faculty Research and Publications

Background

The COVID-19 pandemic has placed an enormous and growing burden on the population and health infrastructure, warranting innovative ways to mitigate risk of contracting and developing severe forms of this disease. A growing body of literature raises the issue of vitamin C and vitamin D as a risk-assessment tool, and therapeutic option, in COVID-19.

Objective

The objective of this pilot study was to measure serum vitamin C and vitamin D levels in a cohort of patients with critical COVID-19 illness in our community hospital ICU, correlate with other illness risk factors (age, BMI, HgbA1c, smoking status), generate hypotheses, and …

Biomaterials In Valvular Heart Diseases, Bita Taghizadeh, Laleh Ghavami, Hossein Derakhshankhah, Ehsan Zangene, Mahdieh Razmi, Mehdi Jaymand, Payam Zarrintaj, Nosratollah Zarghami, Mahmoud Reza Jaafari, Matin Moallem Shahri, Adrineh Moghaddasian, Lobat Tayebi, Zhila Izadi

School of Dentistry Faculty Research and Publications

Valvular heart disease (VHD) occurs as the result of valvular malfunction, which can greatly reduce patient's quality of life and if left untreated may lead to death. Different treatment regiments are available for management of this defect, which can be helpful in reducing the symptoms. The global commitment to reduce VHD-related mortality rates has enhanced the need for new therapeutic approaches. During the past decade, development of innovative pharmacological and surgical approaches have dramatically improved the quality of life for VHD patients, yet the search for low cost, more effective, and less invasive approaches is ongoing. The gold standard approach …

Graphite/Gold Nanoparticles Electrode For Direct Protein Attachment: Characterization And Gas Sensing Application, Javad Shabani Shayeh, Yahya Sefidbakht, Meisam Omidi, Fatemeh Yazdian, Lobat Tayebi

School of Dentistry Faculty Research and Publications

In this work, graphite/gold nanoparticles (G/AuNPs) were synthesized through a facile chemical method, and its potential application for direct protein attachment for electrochemical detection of carbon monoxide (CO) was investigated. The preparation of G/AuNPs electrodes was optimized by synthesizing the nanoparticles in different concentration of HAuCl₄.3H₂O at various temperatures. The G/AuNPs electrode was subsequently modified by four types of mercaptopropionic acid, including 1-mercaptopropionic, 3-mercaptopropionic, 6-mercaptopropionic, and 11-mercaptopropionic acid, to achieve the best structure for protein attachment. Visible absorption and electrochemical studies showed that 3-mercaptopropionic acid possesses the best performance regarding the electrical conductivity between electrode and …

Radiographic Evaluation Of Bone And Mucosa Using Low-Dose Cbct With Radiopaque X-Resin Stent Versus Ct And Ridge Mapping: A Validity Study, Enji Ahmed, Nader Nabil Riskallah, Mushira Muhammed Dahaba, Eman Abdelaziz Ahmed

Dentistry

Aim: To compare the abilities of computed tomography (CT), cone beam computed tomography (CBCT) with X-resin and ridge mapping and to measure the thickness of bone and soft tissue during implant planning, which allows increasing the success criteria of implant placement. Materials and Methods: This validity study included a total of 96 samples chosen from 20 patients undergoing implant surgeries (mandible and maxilla) aged between 25 and 50 years. Measurements of bone and mucosa were done by using three techniques, which are the CT, CBCT with X-resin, and finally ridge mapping at 4 points that are 3, 4, 5, and …

Proanthocyanidin Block Arrays (Pacbar) For Comprehensive Capture And Delineation Of Proanthocyanidin Structures, Shuxi Jing, Wayne E. Zeller, Daneel Ferreira, Bin Zhou, Joo-Won Nam, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

Proanthocyanidins (PACs) are near-ubiquitous and chemically complex metabolites, prototypical of higher plants. Their roles in food/feed/nutrition and ethnomedicine are widely recognized but poorly understood. With the analysis of evidence that underlies this challenge, this perspective identifies shortcomings in capturing and delineating PAC structures as key factors. While several groups have forwarded new representations, a consensus method that captures PAC structures concisely and offers high integrity for electronic storage is required to reduce confusion in this expansive field. The PAC block arrays (PACBAR) system fills this gap by providing precise and human- and machine-readable structural descriptors that capture PAC metabolomic structural …

Targeting Trimeric And Tetrameric Proanthocyanidins Of Cinnamomum Verum Bark As Bioactives For Dental Therapies, Joo-Won Nam, Rasika S. Phansalkar, David C. Lankin, James Mcalpine, Ariene A. Leme-Kraus, Ana K. Bedran-Russo, Shao-Nong Chen, Guido F. Pauli

School of Dentistry Faculty Research and Publications

The present study elucidated the structures of three A-type tri- and tetrameric proanthocyanidins (PACs) isolated from Cinnamomum verum bark to the level of absolute configuration and determined their dental bioactivity using two therapeutically relevant bioassays. After selecting a PAC oligomer fraction via a biologically diverse bioassay-guided process, in tandem with centrifugal partition chromatography, phytochemical studies led to the isolation of PAC oligomers that represent the main bioactive principles of C. verum: two A-type tetrameric PACs, epicatechin-(2β→O→7,4β→8)-epicatechin-(4β→6)-epicatechin-(2β→O→7,4β→8)-catechin (1) and parameritannin A1 (2), together with a trimer, cinnamtannin B1 (3). Structure …

Ada News - 11/16/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Drug-Delivery Ca-Mg Silicate Scaffolds Encapsulated In Plga, A. Jadidi, E. Salahinejad, E. Sharifi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

The aim of this work is to develop dual-functional scaffolds for bone tissue regeneration and local antibiotic delivery applications. In this respect, bioresorbable bredigite (Ca₇MgSi₄O₁₆) porous scaffolds were fabricated by a foam replica method, loaded with vancomycin hydrochloride and encapsulated in poly lactic-co-glycolic acid (PLGA) coatings. Field emission scanning electron microscopy, Archimedes porosimetry and Fourier-transform infrared spectroscopy were used to characterize the structure of the scaffolds. The drug delivery kinetics and cytocompatibility of the prepared scaffolds were also studied in vitro. The bare sample exhibited a burst release of vancomycin and low biocompatibility …

Synergistic Effects Of Conductive Pva/Pedot Electrospun Scaffolds And Electrical Stimulation For More Effective Neural Tissue Engineering, Ali Babaie, Behnaz Bakhshandeh, Ali Abedi, Javad Mohammadnejad, Iman Shabani, Abdolreza Ardeshirylajimi, Seyed Reza Moosavi, Javid Amini, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Fabrication and optimization of conductive scaffolds capable of inducing proper intercellular connections through electrical signals is critical for neural tissue engineering. In this research, electrospun conductive PVA (Polyvinyl alcohol)/PEDOT(poly(3,4-ethylenedioxythiophene)) scaffolds were fabricated in different compositions. Conductivity of electrospinning solutions and electrospun scaffolds were measured. Morphology and topography, mechanical properties and water contact angle of scaffolds were analyzed. Chemistry of scaffolds were studied using FTIR analysis, while biocompatibility and cellular interactions with scaffolds were tested using MTT assay and cellular attachment and spreading testing. Our results show improvements in PEDOT-containing scaffolds, in terms of physiochemical properties, and cell viability compared to …

Blood Pressure Monitoring Following Individual Carpules Of Anesthetic Utilizing Computer-Controlled Anesthetic Delivery, Kristi M. Soileau, Adam E. Degenova, Qingzhao Yu

School of Dentistry Faculty Publications

To date, no study has evaluated blood pressure following administration of each carpule given for dental procedures using a computerized dental anesthesia system. Blood pressures taken prior to performing invasive periodontal procedures were compared with those readings measured following delivery of each of up to three consecutive carpules of Marcaine or Xylocaine in varying order. Pressure differences were also adjusted for age, sex, race, and whether a prescribed anxiolytic was taken beforehand. Neither systolic nor diastolic blood pressures changed significantly as compared to initial blood pressure readings. However, compared with Whites, Hispanics, and Middle Easterners, Blacks had significantly higher systolic …

Ada News - 11/02/2020, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Ada Code Of Ethics (November 2020), American Dental Association

Code of Ethics

The ADA Code of Ethics has three main components: The Principles of Ethics, the Code of Professional Conduct and the Advisory Opinions. Contents may also include: Amendment to ADA Principles of Ethics and Code of Professional Conduct and Insert for the ADA Principles of Ethics and Code of Professional Conduct. The most current issue is available on the ADA’s website.

Molar-Incisor Hypomineralization Studies, Azza Tagelsir Ahmed, Brian Hodgson, E. Angeles Martinez-Mier

School of Dentistry Faculty Research and Publications

The problem of demarcated hypomineralization defects of the permanent first molars (molar-incisor hypomineralization [MIH]) has been an emerging issue for oral health professionals around the globe. Yet, the first set of US-based epidemiologic data on MIH took as long as 2 decades from the time when MIH was first described by Weerheijm and colleagues.¹ In response to the June JADA article titled “Prevalence of Molar-Incisor Hypomineralization and Other Enamel Defects and Associated Sociodemographic Determinants in Indiana,” (Tagelsir Ahmed A, Soto-Rojas AE, Dean JA, Eckert GJ, Martinez-Mier EA, JADA. 2020;151[7]: 491-501), we attempt to highlight some of the challenges encountered …

Nano-Hydroxyapatite And Nano-Hydroxyapatite/Zinc Oxide Scaffold For Bone Tissue Engineering Application, Fatemeh Heidari, Reza Bazargan-Lari, Mehdi Razavi, Farahnaz Fahimipour, Daryoosh Vashaee, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This research aims to evaluate the mechanical properties, biocompatibility, and degradation behavior of scaffolds made of pure hydroxyapatite (HA) and HA‐modified by ZnO for bone tissue engineering applications. HA and ZnO were developed using sol‐gel and precipitation methods respectively. The scaffolds properties were characterized using X‐ray diffraction (XRD), Fourier transform spectroscopy (FTIR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), atomic absorption (AA), and atomic force microscopy (AFM). The interaction of scaffold with cells was assessed using in vitro cell proliferation and alkaline phosphatase (ALP) assays. The obtained results indicate that the HA/ZnO scaffolds possess higher …

A New Phantom To Evaluate The Tissue Dissolution Ability Of Endodontic Irrigants And Activating Devices, Kimia Khoshroo, Brinda Shah, Alexander Johnson, John Baeten, Katherine Barry, Mohammadreza Tahiri, Mohamed Ibrahim, Lobat Tayebi

School of Dentistry Faculty Research and Publications

Abstract

Objective

The aim of this study was to introduce a gelatin/bovine serum albumin (BSA) tissue standard, which provides dissolution properties identical to those of biological tissues. Further, the study evaluated whether the utilization of endodontic activating devices led to enhanced phantom dissolution rates.

Materials and Methods

Bovine pulp tissue was obtained to determine a benchmark of tissue dissolution. The surface area and mass of samples were held constant while the ratio of gelatin and BSA were varied, ranging from 7.5% to 10% gelatin and 5% BSA. Each sample was placed in an individual test tube that was filled with …

Plga-Coated Drug-Loaded Nanotubes Anodically Grown On Nitinol, F. Davoodian, E. Salahinejad, E. Sharifi, Z. Barabadi, Lobat Tayebi

School of Dentistry Faculty Research and Publications

This study evaluates the use of nanotubes (NTs) as a matrix for local drug delivery modified by a biodegradable polymeric coating on medical-grade nitinol (NiTi alloy) surfaces. For this purpose, NiTi was anodized within parameters that promote the formation of NTs, ultrasonicated, annealed and impregnated with vancomycin hydrochloride. To improve bioperformance, poly(lactic-co-glycolic acid) (PLGA) was also deposited on the drug-loaded NTs. The samples were characterized in terms of structure, wettability, drug delivery, corrosion and cytocompatibility. Scanning electron microscopy and water contact angle measurements signify the formation of open-top homogeneous NTs of 600– 700 nm in length and ~30 nm in …

Correlation Between Root Surface Strain And Apical Micro-Cracks Produced During Canal Preparation With Thermally Treated Single Or Multi-File Niti Systems, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: To determine the apical root surface strain (RSS) generated during shaping with thermally treated file NiTi systems, and its association with the development of apical microcracks. Methodology: Twenty extracted human mandibular molars with severely curved mesial roots having two separate canals were prepared using XP-Endo Shaper files (Group A: XPS in mesio-buccal canals) and Hyflex CM files (Group B: HCM in mesio-lingual canals). Pre-instrumentation images of apical surface of each root were obtained with Environmental Scanning Electron Microscope (ESEM). Root surface strain (RSS) generated during canal preparation was measured as micro-strain (ìstrain) using electrical strain gauges fixed on apical …

Antibacterial Potential Of Nano-Particulate Intracanal Medications On A Mature E. Faecalis Biofilm In An Ex Vivo Model, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Aim: To investigate and compare the antibacterial and antibiofilm activity of Chlorhexidine Digluconate functionalized Hydroxyapatite Nanoparticles and silver Nanoparticles as intracanal medicaments on a mature E. faecalis biofilm model in root canals of extracted teeth. Methodology: Sixty-eight human maxillary central incisors were mechanically prepared, sterilized, infected with E. faecalis, and then incubated for 28 days under anaerobic conditions to develop a mature E. faecalis biofilm. Eight teeth were used to monitor biofilm formation and maturation over the incubation period with field emission scanning electron microscopy (Fe SEM), while the other 60 teeth were divided into two experimental groups (n=20) in …

Oral Microbiome And Gingival Tissue Apoptosis And Autophagy Transcriptomics, Jeffrey L. Ebersole, Sreenatha S. Kirakodu, Elliot Neumann, Luis Orraca, Janis Gonzalez Martinez, Octavio A. Gonzalez

Dental Medicine Faculty Publications

Objective: This study focused on documenting characteristics of the gingival transcriptome during various stages of periodontitis targeting genes associated with apoptotic and autophagic pathways and changes that specifically associate with features of the oral microbiome. Methods: Macaca mulatta (n = 18; 12-23 years) were examined at baseline and 0.5, 1, and 3 months of disease progression, as well as 5 months with clinical disease resolution. 16S sequencing and microarray analyses examined changes in the microbiome and gingival transcriptome, respectively, at each time point from every animal. Results: Specific patterns of apoptotic and autophagic genes were identified related to the initiation …