Open Access. Powered by Scholars. Published by Universities.®
- Keyword
Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Chemokine Function In Periodontal Disease And Oral Cavity Cancer, Sinem Esra Sahingur, W. Andrew Yeudall
Chemokine Function In Periodontal Disease And Oral Cavity Cancer, Sinem Esra Sahingur, W. Andrew Yeudall
Periodontics Publications
The chemotactic cytokines, or chemokines, comprise a superfamily of polypeptides with a wide range of activities that include recruitment of immune cells to sites of infection and inflammation, as well as stimulation of cell proliferation. As such, they function as antimicrobial molecules and play a central role in host defenses against pathogen challenge. However, their ability to recruit leukocytes and potentiate or prolong the inflammatory response may have profound implications for the progression of oral diseases such as chronic periodontitis, where tissue destruction may be widespread. Moreover, it is increasingly recognized that chronic inflammation is a key component of tumor …
Identification Of Small-Molecule Inhibitors Against Meso-2, 6-Diaminopimelate Dehydrogenase From Porphyromonas Gingivalis, Victoria N. Stone, Hardik I. Parikh, Fadi El-Rami, Xiuchun Ge, Weihau Chen, Yan Zhang, Glen E. Kellogg, Ping Xu
Identification Of Small-Molecule Inhibitors Against Meso-2, 6-Diaminopimelate Dehydrogenase From Porphyromonas Gingivalis, Victoria N. Stone, Hardik I. Parikh, Fadi El-Rami, Xiuchun Ge, Weihau Chen, Yan Zhang, Glen E. Kellogg, Ping Xu
Philips Institute for Oral Health Research Publications
Species-specific antimicrobial therapy has the potential to combat the increasing threat of antibiotic resistance and alteration of the human microbiome. We therefore set out to demonstrate the beginning of a pathogen-selective drug discovery method using the periodontal pathogen Porphyromonas gingivalis as a model. Through our knowledge of metabolic networks and essential genes we identified a “druggable” essential target, meso-diaminopimelate dehydrogenase, which is found in a limited number of species. We adopted a high-throughput virtual screen method on the ZINC chemical library to select a group of potential small-molecule inhibitors. Meso-diaminopimelate dehydrogenase from P. gingivaliswas first expressed …
Osseointegration Of Wrapped Dental Implants In Rabbits, Alex Whitehead
Osseointegration Of Wrapped Dental Implants In Rabbits, Alex Whitehead
AUCTUS: The Journal of Undergraduate Research and Creative Scholarship
Edentulous patients (those lacking teeth) require one of two approaches to augmentation: inserting a vertical bone graft, or subperiosteally anchoring a device on which an implant can be attached. Bone grafts have had unpredictable results and can undergo resorption over time, compromising implant stability and success. As of the subperiosteal approach, current materials have not proven to directly integrate with the bone, in a process termed osseointegration. Therefore, we used additive manufacturing to create a Ti6Al4V alloy surface with a specific roughness to determine if it would be osseoinductive in a challenging rabbit model over six weeks.
Computer Simulation Of Tooth Mobility Using Varying Material Properties, Allison R. Beckmann, Lena Unterberg, Stefan Raith, Horst Fischer
Computer Simulation Of Tooth Mobility Using Varying Material Properties, Allison R. Beckmann, Lena Unterberg, Stefan Raith, Horst Fischer
AUCTUS: The Journal of Undergraduate Research and Creative Scholarship
Tooth mobility is the major cause of stress on a tooth implant or partial denture and often results in the damage of the device. For many prosthetic devices like dental bridges, a partial denture used for a person who is missing a tooth to give the appearance and function of a tooth, mobility can cause up to double the amount of stress in comparison to a fixed model. Creating a computer simulation of tooth mobility using Finite Element Analysis allows one to understand and predict this movement in order to improve future dental prosthetic devices. The main cause of tooth …