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Full-Text Articles in Medicine and Health Sciences
Aptamer-Conjugated Plga Nanoparticles For Delivery And Imaging Of Cancer Therapeutic Drugs, Maryam Hashemi, Azarmidokht Shamshiri, Majid Saeedi, Lobat Tayebi, Rezvan Yazdian-Robati
Aptamer-Conjugated Plga Nanoparticles For Delivery And Imaging Of Cancer Therapeutic Drugs, Maryam Hashemi, Azarmidokht Shamshiri, Majid Saeedi, Lobat Tayebi, Rezvan Yazdian-Robati
School of Dentistry Faculty Research and Publications
Most problems associated with chemotherapeutic agents involve non-specific cytotoxicity, low intratumoral accumulation and drug resistance. Targeted drug delivery systems (TDDS) based on nanoparticles (NPs) are a new strategy for better therapeutic efficiency, along with reduction of side effects commonly seen with cancer drugs. Poly (lactic-co-glycolic acid) (PLGA), as one of the furthest developed synthetic polymer, has gained significant attention because of excellent properties—including biodegradability and biocompatibility, controlled release of drug, protection of drug or gene from decomposition and ability to modify surface with targeting agents for both cancer diagnosis and therapy. Aptamers are single-stranded RNA or DNA that can fold …
Aptamer Hybrid Nanocomplexes As Targeting Components For Antibiotic/Gene Delivery Systems And Diagnostics: A Review, Navid Rabiee, Sepideh Ahmadi, Zeynab Arab, Mojtaba Bagherzadeh, Moein Safarkhani, Behzad Nasseri, Mohammad Rabiee, Mohammadreza Tahriri, Thomas J. Webster, Lobat Tayebi
Aptamer Hybrid Nanocomplexes As Targeting Components For Antibiotic/Gene Delivery Systems And Diagnostics: A Review, Navid Rabiee, Sepideh Ahmadi, Zeynab Arab, Mojtaba Bagherzadeh, Moein Safarkhani, Behzad Nasseri, Mohammad Rabiee, Mohammadreza Tahriri, Thomas J. Webster, Lobat Tayebi
School of Dentistry Faculty Research and Publications
With the passage of time and more advanced societies, there is a greater emergence and incidence of disease and necessity for improved treatments. In this respect, nowadays, aptamers, with their better efficiency at diagnosing and treating diseases than antibodies, are at the center of attention. Here, in this review, we first investigate aptamer function in various fields (such as the detection and remedy of pathogens, modification of nanoparticles, antibiotic delivery and gene delivery). Then, we present aptamer-conjugated nanocomplexes as the main and efficient factor in gene delivery. Finally, we focus on the targeted co-delivery of genes and drugs by nanocomplexes, …
Recent Advancements In Aptamer-Bioconjugates: Sharpening Stones For Breast And Prostate Cancers Targeting, Saeid Maghsoudi, Bahareh Taghavi Shahraki, Navid Rabiee, Ronak Afshari, Yousef Fatahi, Rassoul Dinarvand, Sepideh Ahmadi, Mojtaba Bagherzadeh, Mohammad Rabiee, Lobat Tayebi, Mohammadreza Tahriri
Recent Advancements In Aptamer-Bioconjugates: Sharpening Stones For Breast And Prostate Cancers Targeting, Saeid Maghsoudi, Bahareh Taghavi Shahraki, Navid Rabiee, Ronak Afshari, Yousef Fatahi, Rassoul Dinarvand, Sepideh Ahmadi, Mojtaba Bagherzadeh, Mohammad Rabiee, Lobat Tayebi, Mohammadreza Tahriri
School of Dentistry Faculty Research and Publications
Breast and prostate cancers are common types of cancers with various strategies, such as chemotherapy and radiotherapy, for their therapy. Since these methods have undesired side effects and poor target affinity, neoteric strategies—known as aptamer-based smart drug delivery systems (SDDSs)—have been developed in recent years to overcome the obstacles of current treatment, and investigated for a clinical trial. The high affinity and versatility of aptamers for binding to the corresponding targets make them highly noticeable agents in the drug delivery domains. In addition to their exceptional benefits, aptamers are able to overcome tumor resistance because of their high selectivity and …