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Full-Text Articles in Medicine and Health Sciences
The Role Of Efferent Reduction Of Cochlear Compression In The Detection Of Tones In Noise, Shaum Bhagat, Anusha Yellamsetty
The Role Of Efferent Reduction Of Cochlear Compression In The Detection Of Tones In Noise, Shaum Bhagat, Anusha Yellamsetty
Faculty Publications
Stimulation of medial olivocochlear (MOC) efferent neurons reduces basilar membrane (BM) sensitivity and increases the slope of BM input-output (I/O) functions in animal models. Decreased compression of I/O functions associated with activation of MOC efferent neurons may assist in extending the neural response to the tone above that of noise, leading to an improvement in masked thresholds. To evaluate this hypothesis, the distortion-product otoacoustic emission (DPOAE) I/O function, a proxy measure of BM compression, was examined in conditions with presentation of contralateral noise. DPOAE I/O functions were measured at f2 frequencies of 1000 and 2000 Hz in 16 normal-hearing adults. …
Monitoring Carboplatin Ototoxicity With Distortion-Product Otoacoustic Emissions In Children With Retinoblastoma, Shaum Bhagat, Johnnie Bass, Stephanie White, Ibrahim Qaddoumi, Matthew Wilson, Jianrong Wu, Carlos Rodriguez-Galindo
Monitoring Carboplatin Ototoxicity With Distortion-Product Otoacoustic Emissions In Children With Retinoblastoma, Shaum Bhagat, Johnnie Bass, Stephanie White, Ibrahim Qaddoumi, Matthew Wilson, Jianrong Wu, Carlos Rodriguez-Galindo
Faculty Publications
ObjectiveCarboplatin is a common chemotherapy agent with potential ototoxic side effects that is used to treat a variety of pediatric cancers, including retinoblastoma. Retinoblastoma is a malignant tumor of the retina that is usually diagnosed in young children. Distortion-product otoacoustic emission tests offer an effective method of monitoring for ototoxicity in young children. This study was designed to compare measurements of distortion-product otoacoustic emissions obtained before and after several courses of carboplatin chemotherapy in order to examine if (a) mean distortion-product otoacoustic emission levels were significantly different; and (b) if criterion reductions in distortion-product otoacoustic emission levels were observed in …