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Full-Text Articles in Medicine and Health Sciences
Time-Frequency Analysis Of Transient-Evoked Otoacoustic Emissions In Children Exposed To Carboplatin Chemotherapy, Shaum Bhagat, Johnnie Bass, Ibrahim Qaddoumi, Rachel Brennan, Matthew Wilson, Jianrong Wu, Carlos-Rodriguez Galindo, Alessia Paglialonga, Gabriella Tognola
Time-Frequency Analysis Of Transient-Evoked Otoacoustic Emissions In Children Exposed To Carboplatin Chemotherapy, Shaum Bhagat, Johnnie Bass, Ibrahim Qaddoumi, Rachel Brennan, Matthew Wilson, Jianrong Wu, Carlos-Rodriguez Galindo, Alessia Paglialonga, Gabriella Tognola
Faculty Publications
The aims of this study were to characterize and quantify time-frequency changes in transient-evoked otoacoustic emissions (TEOAEs) recorded in children diagnosed with retinoblastoma who were receiving carboplatin chemotherapy. A signal processing technique, the wavelet transform (WT), was used to analyze TEOAE waveforms in narrow-band frequency components. Ten children (aged 3–72 months) diagnosed with unilateral or bilateral retinoblastoma were enrolled in the study. TEOAEs were acquired from the children with linear sequences of 70 dB peak equivalent SPL clicks. After WT analysis, TEOAE energy, latency and normalized energy in the narrow-band frequency components were compared before and during carboplatin chemotherapy treatment …
Monitoring Carboplatin Ototoxicity With Distortion-Product Otoacoustic Emissions In Children With Retinoblastoma, Shaum Bhagat, Johnnie Bass, Stephanie White, Ibrahim Qaddoumi, Matthew Wilson, Jianrong Wu, Carlos Rodriguez-Galindo
Monitoring Carboplatin Ototoxicity With Distortion-Product Otoacoustic Emissions In Children With Retinoblastoma, Shaum Bhagat, Johnnie Bass, Stephanie White, Ibrahim Qaddoumi, Matthew Wilson, Jianrong Wu, Carlos Rodriguez-Galindo
Faculty Publications
ObjectiveCarboplatin is a common chemotherapy agent with potential ototoxic side effects that is used to treat a variety of pediatric cancers, including retinoblastoma. Retinoblastoma is a malignant tumor of the retina that is usually diagnosed in young children. Distortion-product otoacoustic emission tests offer an effective method of monitoring for ototoxicity in young children. This study was designed to compare measurements of distortion-product otoacoustic emissions obtained before and after several courses of carboplatin chemotherapy in order to examine if (a) mean distortion-product otoacoustic emission levels were significantly different; and (b) if criterion reductions in distortion-product otoacoustic emission levels were observed in …