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Full-Text Articles in Medicine and Health Sciences
Gastrin Induces Nuclear Export And Proteasomal Degradation Of Menin In Enteric Glial Cells, Sinju Sundaresan, Cameron A. Meininger, Anthony J. Kang, Amanda L. Photenhauer, Michael M. Hayes, Nirakar Sahoo, Jolanda Lindenberg, Jolanta Grembecka, Tomasz Cierpicki, Lin Ding
Gastrin Induces Nuclear Export And Proteasomal Degradation Of Menin In Enteric Glial Cells, Sinju Sundaresan, Cameron A. Meininger, Anthony J. Kang, Amanda L. Photenhauer, Michael M. Hayes, Nirakar Sahoo, Jolanda Lindenberg, Jolanta Grembecka, Tomasz Cierpicki, Lin Ding
Biology Faculty Publications and Presentations
Background & aims: The multiple endocrine neoplasia, type 1 (MEN1) locus encodes the nuclear protein and tumor suppressor menin. MEN1 mutations frequently cause neuroendocrine tumors such as gastrinomas, characterized by their predominant duodenal location and local metastasis at time of diagnosis. Diffuse gastrin cell hyperplasia precedes the appearance of MEN1 gastrinomas, which develop within submucosal Brunner's glands. We investigated how menin regulates expression of the gastrin gene and induces generation of submucosal gastrin-expressing cell hyperplasia.
Methods: Primary enteric glial cultures were generated from the VillinCre:Men1FL/FL:Sst-/- mice or C57BL/6 mice (controls), with or without inhibition of gastric acid by omeprazole. Primary …