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Full-Text Articles in Medicine and Health Sciences
Increased Number Of Circulating Exosomes And Their Microrna Cargos Are Potential Novel Biomarkers In Alcoholic Hepatitis, Fatemeh Momen-Heravi, Banishree Saha, Karen Kodys, Donna Catalano, Abhishek Satishchandran, Gyongyi Szabo
Increased Number Of Circulating Exosomes And Their Microrna Cargos Are Potential Novel Biomarkers In Alcoholic Hepatitis, Fatemeh Momen-Heravi, Banishree Saha, Karen Kodys, Donna Catalano, Abhishek Satishchandran, Gyongyi Szabo
Gyongyi Szabo
BACKGROUND: It has been well documented that alcohol and its metabolites induce injury and inflammation in the liver. However, there is no potential biomarker to monitor the extent of liver injury in alcoholic hepatitis patients. MicroRNAs (miRNAs) are a class of non-coding RNAs that are involved in various physiologic and pathologic processes. In the circulation, a great proportion of miRNAs is associated with extracellular vesicles (EVs)/exosomes. Here, we hypothesized that the exosome-associated miRNAs can be used as potential biomarkers in alcoholic hepatitis (AH).
METHODS: Exosomes were isolated from sera of alcohol-fed mice or pair-fed mice, and plasma of alcoholic hepatitis …
The Metabolism Of Alcohol: Risk And Protective Factors, Sydney E. Levan, Amy Adkins, Danielle Dick, Karen G. Chartier
The Metabolism Of Alcohol: Risk And Protective Factors, Sydney E. Levan, Amy Adkins, Danielle Dick, Karen G. Chartier
Undergraduate Research Posters
Purpose: Abstract for poster submission to VCU Poster Symposium for
Undergraduate Research and Creativity
Title: The Metabolism of Alcohol: Risk and Protective Factors
Background: In 2002, it was reported by the National Institutes of Health that
60.3% of college aged students (18-22) drank alcohol in the past month of being
asked, as compared to 51.9% of those not in college. They also found that 20% of
college students met the criteria for at least one alcohol use disorder (AUDs)1.
Many genes have been linked to an increased risk for AUDs and how individuals
with various ethnic backgrounds respond to alcohol. …