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Full-Text Articles in Medicine and Health Sciences
“Effects Of N-3 And N-6 Polyunsaturated Fatty Acids On Human Promyelocytic Hl- 60 Cells, Robert Clements Gillis
“Effects Of N-3 And N-6 Polyunsaturated Fatty Acids On Human Promyelocytic Hl- 60 Cells, Robert Clements Gillis
Doctoral Dissertations
Enteral nutrition with eicosapentaenoic acid (EPA; 20:5 n-3) and γ-linolenic acid (GLA; 18:3 n-6) decreased pulmonary inflammation by reducing neutrophil counts and chemotactic factors in bronchoalveolar lavage fluid during acute respiratory distress syndrome (ARDS). We hypothesize that the antiinflammatory effects of EPA and GLA may be due, in part, to induction of neutrophil apoptosis. Neutrophil apoptosis is an important physiological process in the resolution of pulmonary inflammation. Furthermore, pro-inflammatory eicosanoids formed from arachidonic acid (AA) by lipoxygenase (LO) and cyclooxygenase (COX) pathways have been shown to inhibit apoptosis in certain cell types. The purpose of this dissertation is to determine …